Document Detail


Mechanisms of atrial fibrillation: mother rotors or multiple daughter wavelets, or both?
MedLine Citation:
PMID:  9727669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of atrial fibrillation (AF) remains poorly understood. In this article, we present a new unifying hypothesis for the electrophysiologic basis of AF. We surmise that sustained AF depends on the uninterrupted periodic activity of discrete reentrant sites. The shorter reentrant circuits act as dominant frequency sources that maintain the overall activity. The rapidly succeeding wavefronts emanating from these sources propagate through both atria and interact with anatomic and/or functional obstacles, leading to the phenomenon of "vortex shedding" and to wavelet formation. As suggested by recent numerical and experimental results from our laboratory, some of such wavelets may shrink and undergo decremental conduction, others may be annihilated by collision with another wavelet or a boundary, and still others may curl to create new vortices. The end result would be the fragmentation of the periodic wavefronts into multiple independent daughter wavelets, giving rise to new wavelets, and so on in the ceaseless, globally aperiodic motion that characterizes fibrillatory conduction.
Authors:
J Jalife; O Berenfeld; A Skanes; R Mandapati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  9     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-11-30     Completed Date:  1998-11-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S2-12     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, SUNY Health Science Center, Syracuse, New York 13210, USA. jalifej@vax.cs.hscsyr.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Fibrillation / physiopathology*
Electrophysiology
Humans
Grant Support
ID/Acronym/Agency:
P01-HL39707/HL/NHLBI NIH HHS

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