| Mechanisms of apoptosis in retinitis pigmentosa. | |
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MedLine Citation:
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PMID: 19355918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mutations in humans are associated with several forms of inherited retinal dystrophies, such as Retinitis Pigmentosa which lead to retinal cell death and irreversible loss of vision. Genes involved in affected patients mainly encode proteins related to vision physiology including visual cycle and light-dependent phototransduction cascade. As reported in spontaneous and genetically engineered mouse models, apoptosis is a common fate in retinal degeneration, although the triggered signals to retinal apoptosis remain largely unraveled. Several studies highlighted that many of the molecular pathways involved in ocular diseases rely on caspase-dependent or -independent apoptotic mitochondrial pathway involving the Bcl-2 family of proteins. Anti- and pro-apoptotic Bcl-2 members are present in retinal tissues and are thought to play a role in the pathogenesis of several retinal disorders. Since almost no efficient treatments are available so far, it remains a great challenge to decipher the molecular pathways involved in retinal dystrophies and to develop alternative therapies to prevent or inhibit eye defect. Toward this goal, mutation-independent strategies such as molecular therapy provides promising and exciting approaches to deliver anti-apoptotic molecules targeting the Bcl-2 pathway through the use of cell permeable transport peptides. Modulation of common apoptotic signaling pathways may be of outstanding potential to target multiple retinal dystrophies regardless of the primary genetic defect. |
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Authors:
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Sandra Cottet; Daniel F Schorderet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current molecular medicine Volume: 9 ISSN: 1566-5240 ISO Abbreviation: Curr. Mol. Med. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-09 Completed Date: 2009-05-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093076 Medline TA: Curr Mol Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 375-83 Citation Subset: IM |
Affiliation:
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IRO, Institute for Research in Ophthalmology, Sion, Switzerland. sandra.cottet@irovision.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology* Caspases / metabolism Humans Light Signal Transduction / physiology Mutation Retinitis Pigmentosa / genetics, pathology*, physiopathology* Signal Transduction / physiology |
| Chemical | |
Reg. No./Substance:
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EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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