Document Detail

Mechanisms of anionic detergent-induced hemolysis.
MedLine Citation:
PMID:  9834847     Owner:  NLM     Status:  MEDLINE    
The effect of osmotic protectors (sucrose and polyethylene glycols) and of a decrease in the detergent concentration at different points of hemolysis of human erythrocytes by sodium dodecyl sulphate on the shape of kinetic curves of hemolysis were studied. It is shown that slow detergent-induced hemolysis follows the colloid-osmotic mechanisms. Evidence is provided that rapid hemolysis by sodium dodecyl sulphate is caused by opening of large pores sufficient for the release of hemoglobin molecules rather than by the colloid-osmotic mechanism, and that the kinetics of hemolysis is mainly determined by time dependence of the opening probability of these pores.
E Chernitsky; O Senkovich
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  General physiology and biophysics     Volume:  17     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-02-19     Completed Date:  1999-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  SLOVAKIA    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  IM    
Institute of Photobiology, National Academy of Sciences of Belarus, Minsk, Belarus.
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MeSH Terms
Erythrocytes / drug effects*,  physiology
Hemolysis / drug effects*,  physiology
Polyethylene Glycols / pharmacology
Sodium Dodecyl Sulfate / pharmacology*
Sucrose / pharmacology
Surface-Active Agents / pharmacology*
Reg. No./Substance:
0/Polyethylene Glycols; 0/Surface-Active Agents; 151-21-3/Sodium Dodecyl Sulfate; 57-50-1/Sucrose

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