Document Detail


Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism.
MedLine Citation:
PMID:  23212075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of amino acids in the regulation of insulin secretion in pancreatic beta-cells is highlighted in three forms of congenital hyperinsulinism (HI), namely gain-of-function mutations of glutamate dehydrogenase (GDH), loss-of-function mutations of ATP-dependent potassium channels, and a deficiency of short-chain 3-hydroxyacyl-CoA dehydrogenase. Studies on disease mouse models of HI suggest that amino acid oxidation and signaling effects are the major mechanisms of amino acid-stimulated insulin secretion. Amino acid oxidation via GDH produces ATP and triggers insulin secretion. The signaling effect of amino acids amplifies insulin release after beta-cell depolarization and elevation of cytosolic calcium.
Authors:
Tingting Zhang; Changhong Li
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-12-04
Journal Detail:
Title:  Acta biochimica et biophysica Sinica     Volume:  45     ISSN:  1745-7270     ISO Abbreviation:  Acta Biochim. Biophys. Sin. (Shanghai)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-21     Completed Date:  2013-06-04     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101206716     Medline TA:  Acta Biochim Biophys Sin (Shanghai)     Country:  China    
Other Details:
Languages:  eng     Pagination:  36-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxyacyl CoA Dehydrogenases / genetics
Adenosine Triphosphate / biosynthesis
Amino Acids / physiology*
Animals
Congenital Hyperinsulinism / metabolism*
Glutamate Dehydrogenase / genetics
Humans
Insulin / secretion*
Mice
Mutation
Oxidation-Reduction
Potassium Channels / genetics
Signal Transduction
Transgenes
Grant Support
ID/Acronym/Agency:
DK19525/DK/NIDDK NIH HHS; DK22122/DK/NIDDK NIH HHS; DK53012/DK/NIDDK NIH HHS; U01DK089529/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Insulin; 0/Potassium Channels; 8L70Q75FXE/Adenosine Triphosphate; EC 1.1.1.-/3-Hydroxyacyl CoA Dehydrogenases; EC 1.4.1.2/Glutamate Dehydrogenase
Comments/Corrections

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