| Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism. | |
| | |
MedLine Citation:
|
PMID: 23212075 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The role of amino acids in the regulation of insulin secretion in pancreatic beta-cells is highlighted in three forms of congenital hyperinsulinism (HI), namely gain-of-function mutations of glutamate dehydrogenase (GDH), loss-of-function mutations of ATP-dependent potassium channels, and a deficiency of short-chain 3-hydroxyacyl-CoA dehydrogenase. Studies on disease mouse models of HI suggest that amino acid oxidation and signaling effects are the major mechanisms of amino acid-stimulated insulin secretion. Amino acid oxidation via GDH produces ATP and triggers insulin secretion. The signaling effect of amino acids amplifies insulin release after beta-cell depolarization and elevation of cytosolic calcium. |
| | |
Authors:
|
Tingting Zhang; Changhong Li |
Related Documents
:
|
23632325 - Valproic acid-induced parkinsonism: levodopa responsiveness with dyskinesia. 1761415 - Structures of aureobasidins b to r. 20431615 - Aqabamycins a-g: novel nitro maleimides from a marine vibrio species: ii. structure elu... 1406345 - Structure activity relationships of stendomycin, a lipopeptide antibiotic from streptom... 6323855 - Inhibition of the stimulated exocrine pancreas by absorbed amino acids. 11378415 - Stereospecificity of the (z)-9 desaturase that converts (e)-11-tetradecenoic acid into ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-4 |
Journal Detail:
|
Title: Acta biochimica et biophysica Sinica Volume: - ISSN: 1745-7270 ISO Abbreviation: Acta Biochim. Biophys. Sin. (Shanghai) Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101206716 Medline TA: Acta Biochim Biophys Sin (Shanghai) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorgani...
Next Document: Dual roles of PKM2 in cancer metabolism.