Document Detail

Mechanisms of aluminum-induced microcytosis: lessons from accidental aluminum intoxication.
MedLine Citation:
PMID:  7731142     Owner:  NLM     Status:  MEDLINE    
Twenty-three hemodialysis patients exposed to an accidental aluminum overload, showed increased erythropoietin requirements and decreased erythrocyte mean corpuscular volume (MCV). At the peak of the intoxication, MCV and plasma aluminum levels changed from unrelated (r = 0.02) to strongly related (r = 0.425) variables. The molar proportion of plasma aluminum to plasma iron increased dramatically (from 1:13.8 to 1:2.4). This significant increment in the aluminum/iron ratio made higher the relative offer of aluminum with respect to iron to the erythroid precursor cells. Accordingly, in a subset of 13 randomly selected aluminum-intoxicated patients we found increased intraerythrocytic aluminum, which paralleled the increase in plasma aluminum. Furthermore, in the aluminum-intoxicated group, intraerythrocytic ferritin, a marker of iron content, and the ratio between erythrocyte and plasma ferritin were lower (P < 0.01 and < 0.001, respectively), than in the control group. These findings support the hypothesis that in some cases of aluminum-related microcytosis, a ferropenic mycrocitosis, as expression of erythroid ferropenia, may exist in spite of the presence of normal body iron stores.
C A Caramelo; J B Cannata; M R Rodeles; J L Fernández Martín; J R Mosquera; B Monzú; J Outeiriño; G Blum; C Andrea; A J Lopez Farré
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  47     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-01     Completed Date:  1995-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  164-8     Citation Subset:  IM    
Fundación Jiménez-Díaz, Madrid-Oviedo, Spain.
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MeSH Terms
Aluminum / blood
Aluminum Compounds / poisoning*
Anemia, Iron-Deficiency / blood,  chemically induced*
Erythrocyte Count
Erythrocyte Indices
Erythrocytes, Abnormal / metabolism
Ferritins / blood
Iron / blood
Kidney Failure, Chronic / blood,  therapy
Renal Dialysis / adverse effects
Reg. No./Substance:
0/Aluminum Compounds; 7429-90-5/Aluminum; 7439-89-6/Iron; 9007-73-2/Ferritins

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