| Mechanisms of allergic sensitization to foods: bypassing immune tolerance pathways. | |
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MedLine Citation:
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PMID: 22244229 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The default response of the mucosal immune system to antigens derived from food is one of active immune tolerance carried out by regulatory T cells and induced by dendritic cells residing in the intestinal mucosa. This tolerance response must be inhibited or bypassed to generate allergic sensitization in experimental food allergy and this has been achieved by 3 main approaches: genetic modifications, experimental adjuvants, and bypassing oral tolerance by administering the antigen through alternative routes. This article discusses the implications of these approaches for understanding the mechanisms of sensitization to food allergens in human disease. |
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Authors:
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M Cecilia Berin |
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Publication Detail:
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Type: Journal Article Date: 2011-12-07 |
Journal Detail:
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Title: Immunology and allergy clinics of North America Volume: 32 ISSN: 1557-8607 ISO Abbreviation: Immunol Allergy Clin North Am Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8805635 Medline TA: Immunol Allergy Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Pediatric Allergy and Immunology, Mount Sinai School of Medicine, Box 1198, One Gustave L. Levy Place, New York, NY 10029, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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