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Mechanisms of action of zinc in acute diarrhea.
MedLine Citation:
PMID:  20856116     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: For over a decade, the importance of zinc in the treatment of acute diarrhea has been recognized. More recently, the mechanisms of action of zinc are becoming clearer. This review is focused on the new evidence on the mechanisms of action of zinc in acute diarrhea.
RECENT FINDINGS: The vast majority of data derive from in-vitro studies using intestinal cell lines or from animal model. The positive action by zinc in acute diarrhea derives from a regulation of intestinal fluid transport, mucosal integrity, immunity, gene expression, and oxidative stress. A complex homeostatic network is also able to regulate zinc status at cellular and extracellular level.
SUMMARY: All these data support the use of zinc in the treatment of acute diarrhea, but further clinical studies are needed to explore the selective effects of zinc against specific pathogens responsible for diarrhea.
Authors:
Roberto Berni Canani; Vittoria Buccigrossi; Annalisa Passariello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in gastroenterology     Volume:  27     ISSN:  1531-7056     ISO Abbreviation:  Curr. Opin. Gastroenterol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506887     Medline TA:  Curr Opin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-12     Citation Subset:  IM    
Affiliation:
aDepartment of Pediatrics bEuropean Laboratory for the Investigation of Food Induced Diseases, University of Naples 'Federico II', Italy cNeonatal Intensive Care Unit, Monaldi Hospital, Naples, Italy.
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