Document Detail


Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol.
MedLine Citation:
PMID:  2044646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of two different plant sterols on intestinal cholesterol absorption were compared in normal volunteers by an intestinal perfusion study during a control period followed by high dose infusion of sitosterol or sitostanol (3.6 mumol/min), to which subjects were allocated in a randomized manner. Cholesterol absorption during the control period was similar in the two groups, averaging 0.88 +/- 0.48 mumol/min (32 +/- 11%) for group I (sitosterol) and 0.68 +/- 0.33 mumol/min (29 +/- 9%) for group II (sitostanol). The infusion of a high dose of sitosterol resulted in a significant reduction of cholesterol absorption to 0.47 mumol/min (16%). Following the same dose of sitostanol, cholesterol absorption diminished significantly to 0.15 +/- 0.11 mumol/min (5.1 +/- 2.9%). Overall cholesterol absorption declined during sitosterol infusion by almost 50%, whereas sitostanol infusion caused a reduction of cholesterol absorption by almost 85%. These findings of a more effective inhibition of cholesterol absorption by sitostanol might confirm the observation recorded by others that an increase in hydrophobicity of a plant sterol results in a higher affinity but lower capacity to mixed micells. This may cause an effective displacement of cholesterol from micellar binding and therefore diminished cholesterol absorption.
Authors:
T Heinemann; G A Kullak-Ublick; B Pietruck; K von Bergmann
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  40 Suppl 1     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-15     Completed Date:  1991-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  S59-63     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Bonn, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Cholesterol / metabolism,  secretion
Cholesterol, Dietary / metabolism*
Humans
Intestinal Absorption / drug effects
Male
Sitosterols / pharmacology*
Chemical
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Sitosterols; 57-88-5/Cholesterol; 5779-62-4/sitosterol; 83-45-4/stigmastanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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