| Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome. | |
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MedLine Citation:
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PMID: 21537962 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Visceral hypersensitivity is currently considered a key pathophysiological mechanism involved in pain perception in large subgroups of patients with functional gastrointestinal disorders, including irritable bowel syndrome (IBS). In IBS, visceral hypersensitivity has been described in 20%-90% of patients. The contribution of the central nervous system and psychological factors to visceral hypersensitivity in patients with IBS may be significant, although still debated. Peripheral factors have gained increasing attention following the recognition that infectious enteritis may trigger the development of persistent IBS symptoms, and the identification of mucosal immune, neural, endocrine, microbiological, and intestinal permeability abnormalities. Growing evidence suggests that these factors play an important role in pain transmission from the periphery to the brain via sensory nerve pathways in large subsets of patients with IBS. In this review, we will report on recent data on mechanisms involved in visceral hypersensitivity in IBS, with particular attention paid to peripheral mechanisms. |
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Authors:
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Giovanni Barbara; Cesare Cremon; Roberto De Giorgio; Giovanni Dothel; Lisa Zecchi; Lara Bellacosa; Giovanni Carini; Vincenzo Stanghellini; Roberto Corinaldesi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
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Title: Current gastroenterology reports Volume: - ISSN: 1534-312X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), University of Bologna, Bologna, Italy, giovanni.barbara@unibo.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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