Document Detail


Mechanisms of sympathetic regulation in orthostatic intolerance.
MedLine Citation:
PMID:  22678960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sympathetic circulatory control is key to the rapid cardiovascular adjustments that occur within seconds of standing upright (orthostasis) and which are required for bipedal stance. Indeed, patients with ineffective sympathetic adrenergic vasoconstriction rapidly develop orthostatic hypotension, prohibiting effective upright activities. One speaks of orthostatic intolerance (OI) when signs, such as hypotension, and symptoms, such as lightheadedness, occur when upright and are relieved by recumbence. The experience of transient mild OI is part of daily life. However, many people experience episodic acute OI as postural faint or chronic OI in the form of orthostatic tachycardia and orthostatic hypotension that significantly reduce the quality of life. Potential mechanisms for OI are discussed including forms of sympathetic hypofunction, forms of sympathetic hyperfunction, and OI that results from regional blood volume redistribution attributable to regional adrenergic hypofunction.
Authors:
Julian M Stewart
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-06-07
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-04-29     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1659-68     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Cardiovascular System / innervation*
Heart Rate
Hemodynamics*
Homeostasis
Humans
Hypotension, Orthostatic / physiopathology
Orthostatic Intolerance / physiopathology*,  therapy
Postural Orthostatic Tachycardia Syndrome / physiopathology
Sympathetic Nervous System / physiopathology*
Syncope, Vasovagal / physiopathology
Vasoconstriction
Grant Support
ID/Acronym/Agency:
R01 HL074873/HL/NHLBI NIH HHS; R01 HL087803/HL/NHLBI NIH HHS; R01 HL112736/HL/NHLBI NIH HHS; R01-HL074873/HL/NHLBI NIH HHS; R01-HL087803/HL/NHLBI NIH HHS
Comments/Corrections

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