| Mechanisms of Sympathetic Regulation in Orthostatic Intolerance. | |
| | |
MedLine Citation:
|
PMID: 22678960 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Sympathetic circulatory control is key to the rapid cardiovascular adjustments that occur within seconds of standing upright (orthostasis) and which are required for bipedal stance. Indeed, patients with ineffective sympathetic adrenergic vasoconstriction rapidly develop "orthostatic hypotension" prohibiting effective upright activities. One speaks of "orthostatic intolerance" (OI) when signs, such as hypotension, and symptoms, such as lightheadedness, occur when upright and are relieved by recumbence. The experience of transient mild OI is part of daily life. However, many people experience episodic acute OI, in the form of postural faint or chronic OI, in the form of orthostatic tachycardia and orthostatic hypotension which significantly reduce the quality of life. Potential mechanisms for OI are discussed including forms of sympathetic hypofunction, forms of sympathetic hyperfunction, and OI that results from regional blood volume redistribution due to regional adrenergic hypofunction. |
| | |
Authors:
|
Julian M Stewart |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-7 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1New York Medical College. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of regional lung inflation on ventilation heterogeneity at different length scales during mec...
Next Document: Melanocortin Receptor Expression Is Associated with Reduced CRP in Response to Resistance Training.