| Mechanisms of statin treatment in cerebral vasospasm. | |
| | |
MedLine Citation:
|
PMID: 21125437 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent experimental evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid hemorrhage. This literature review focuses on the literature-based putative mechanisms involved in statin mediated attenuation of cerebral vasospasm, such as eNOS, vascular inflammation, apoptosis, especially the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway from our experimental study. |
| | |
Authors:
|
Takashi Sugawara; Robert Ayer; Vikram Jadhav; Wanqiu Chen; Tamiji Tsubokawa; John H Zhang |
Related Documents
:
|
15744757 - Legal issues of addiction assessment: the experience with hair testing in greece. 20680187 - Extrapyramidal symptoms associated with antidepressants--a review of the literature and... 1344047 - Diffuse panbronchiolitis observed in an italian male. 17047277 - Non-diverging analytic expression for the on-axis sensitivity of converging collimators... 16043917 - Poliosis circumscripta associated with neurofibroma. 3515937 - Serratia marcescens osteomyelitis of the clavicle and sternoclavicular arthritis compli... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta neurochirurgica. Supplement Volume: 110 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir. Suppl. Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-12-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100962752 Medline TA: Acta Neurochir Suppl Country: Austria |
Other Details:
|
Languages: eng Pagination: 9-11 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92354, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of apolipoprotein e in the pathological events following subarachnoid hemorrhage: a review.
Next Document: The effect of phosphodiesterase inhibitor tadalafil on vasospasm following subarachnoid hemorrhage i...