Document Detail

Mechanisms of Radiation-Induced Sensorineural Hearing Loss and Radioprotection.
MedLine Citation:
PMID:  24650954     Owner:  NLM     Status:  Publisher    
Patients that receive radiotherapy are at risk of late sensorineural hearing loss when the inner ear is included within the radiation field. Preclinical and human temporal bone studies have shown that there is differential damage to cochlear structures depending on the amount of dose delivered to the inner ear. In vitro studies have suggested that reactive oxygen species (ROS) are the main initial actors in radiation-induced damage. The interaction of ROS with different cellular components can result in different apoptotic pathways. Therefore, approaches to radioprotection are mainly aimed to reduce ROS production through antioxidants. This review summarizes recent research in the field that can improve the understanding and boost preventive efforts of this adverse effect.
Mario A Mujica-Mota; Shirley Lehnert; Slobodan Devic; Karina Gasbarrino; Sam J Daniel
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Publication Detail:
Type:  REVIEW     Date:  2014-3-17
Journal Detail:
Title:  Hearing research     Volume:  -     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
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