Document Detail


Mechanisms of propagation of intercellular calcium waves in arterial smooth muscle cells.
MedLine Citation:
PMID:  20643050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In rat mesenteric arteries, smooth muscle cells exhibit intercellular calcium waves in response to local phenylephrine stimulation. These waves have a velocity of approximately 20 cells/s and a range of approximately 80 cells. We analyze these waves in a theoretical model of a population of coupled smooth muscle cells, based on the hypothesis that the wave results from cell membrane depolarization propagation. We study the underlying mechanisms and highlight the importance of voltage-operated channels, calcium-induced calcium release, and chloride channels. Our model is in agreement with experimental observations, and we demonstrate that calcium waves presenting a velocity of approximately 20 cells/s can be mediated by electrical coupling. The wave velocity is limited by the time needed for calcium influx through voltage-operated calcium channels and the subsequent calcium-induced calcium release, and not by the speed of the depolarization spreading. The waves are partially regenerated, but have a spatial limit in propagation. Moreover, the model predicts that a refractory period of calcium signaling may significantly affect the wave appearance.
Authors:
Michèle Koenigsberger; Dominique Seppey; Jean-Louis Bény; Jean-Jacques Meister
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biophysical journal     Volume:  99     ISSN:  1542-0086     ISO Abbreviation:  Biophys. J.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-10-27     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  333-43     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Affiliation:
Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory of Cell Biophysics, Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / metabolism*
Calcium Signaling*
Chloride Channels / metabolism
Electric Conductivity
Extracellular Space / metabolism*
Ion Channel Gating
Mesenteric Arteries / cytology*
Models, Biological
Myocytes, Smooth Muscle / metabolism*
Rats
Chemical
Reg. No./Substance:
0/Chloride Channels; 7440-70-2/Calcium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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