Document Detail


Mechanisms of post-intervention arterial remodelling.
MedLine Citation:
PMID:  22918976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been appreciated over the past two decades that arterial remodelling, in addition to intimal hyperplasia, contributes significantly to the degree of restenosis that develops following revascularization procedures. Remodelling appears to be an adventitia-based process that is contributed to by multiple factors including cytokines and growth factors that regulate extracellular matrix or phenotypic transformation of vascular cells including myofibroblasts. In this review, we summarize the currently available information from animal models as well as clinical investigations regarding arterial remodelling. The factors that contribute to this process are presented with an emphasis on potential therapeutic methods to enhance favourable remodelling and prevent restenosis.
Authors:
Shakti A Goel; Lian-Wang Guo; Bo Liu; K C Kent
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-08-22
Journal Detail:
Title:  Cardiovascular research     Volume:  96     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2013-04-25     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angioplasty / adverse effects*
Animals
Arteries / metabolism,  pathology*
Coronary Artery Disease / therapy*
Coronary Restenosis / etiology*,  metabolism,  pathology,  prevention & control
Coronary Vessels / metabolism,  pathology
Extracellular Matrix Proteins / metabolism
Humans
Neointima
Percutaneous Coronary Intervention / adverse effects*
Peripheral Arterial Disease / therapy*
Phenotype
Recurrence
Signal Transduction
Treatment Outcome
Grant Support
ID/Acronym/Agency:
R01 HL068673/HL/NHLBI NIH HHS; R01-HL-068673/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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