| Mechanisms of Post-Intervention Arterial Remodeling. | |
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MedLine Citation:
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PMID: 22918976 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It has been appreciated over the last two decades that arterial remodeling, in addition to intimal hyperplasia, contributes significantly to the degree of restenosis that develops following revascularization procedures. Remodeling appears to be an adventitia-based process that is contributed to by multiple factors including cytokines and growth factors that regulate extracellular matrix or phenotypic transformation of vascular cells including myofibroblasts. In this review, we summarize the currently available information from animal models as well as clinical investigations regarding arterial remodeling. The factors that contribute to this process are presented with an emphasis on potential therapeutic methods to enhance favorable remodeling and prevent restenosis. |
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Authors:
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Shakti A Goel; Lian-Wang Guo; Bo Liu; K Craig Kent |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-22 |
Journal Detail:
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Title: Cardiovascular research Volume: - ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Surgery, University of Wisconsin, 1111 Highland Ave, Madison, WI 53705. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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