Document Detail


Mechanisms of PCBs mixture toxicity on isolated rat hepatocytes.
MedLine Citation:
PMID:  1909307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure of isolated hepatocytes to a polychlorinated biphenyl mixture induced a rapid loss of cell viability. The effect was not dose-dependent. The biochemical effects in the cellular toxicity did not involve glutathione content, protein sulfhydryl groups and lipid peroxidation. A transient increase in cytosolic Ca2+ was observed after exposing the hepatocytes to the polychlorinated biphenyl mixture. Our findings indicate that polychlorinated biphenyls are able to kill hepatocytes and suggest that elevation of cytosolic Ca2+ concentration could be responsable of the toxicity.
Authors:
L Atzori; C Flore; A M Corriga; P Cherchi; D Casula; L Congiu
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Industrial health     Volume:  29     ISSN:  0019-8366     ISO Abbreviation:  Ind Health     Publication Date:  1991  
Date Detail:
Created Date:  1991-10-09     Completed Date:  1991-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
Affiliation:
Istituto Patologia General, Universita degli Studi, Cagliari, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / metabolism
Cell Survival / physiology
Cytosol / metabolism
Glutathione / metabolism
Liver / drug effects*,  metabolism
Male
Polychlorinated Biphenyls / toxicity*
Rats
Rats, Inbred Strains
Sulfhydryl Compounds / metabolism
Chemical
Reg. No./Substance:
0/Polychlorinated Biphenyls; 0/Sulfhydryl Compounds; 70-18-8/Glutathione; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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