| Mechanisms of Neuronal Damage and Neuroprotection Underlying Ischemia/Reperfusion Injury after Physical Exercise. | |
| | |
MedLine Citation:
|
PMID: 22204323 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The effects of exercise pre-conditioning on lessening the impact of ischemia/reperfusion injury provide pivotal information and potential targets for future pharmacological intervention. Exercise induces increased expression of neurotrophic factors, the extracellular matrix (ECM) proteins, integrins, angiogenic factors, as well as tumor necrosis factor (TNF-α) and heat shock proteins (Hsp-70). These factors all directly enhance the neurovascular unit and alleviate the harmful effects following ischemia/reperfusion injury. Furthermore, pre-conditioning decreases expression of matrix metalloproteinase (MMP-9) and Toll-like receptor-4, which ameliorates the inflammatory response and apoptosis following ischemic insult. Perhaps most importantly, exercise pre-conditioning shows a propensity to simultaneously favor cell survival mechanisms and inhibit apoptotic pathways via interactions between TNF-α and Hsp-70, which are regulated by extracellular signal-regulated kinases-1 and -2 (ERK1/2). Finally, chronic exercise preconditioning increases cerebral metabolism, effectively enhancing the neuronal response to increase ATP production following periods of hypoxia. The purpose of this review is to demonstrate the various effects of exercise pre-conditioning on the neural response to ischemia/reperfusion injury as a means of demonstrating potential targets for prevention and treatment of acute ischemic events. |
| | |
Authors:
|
David Dornbos; Yuchuan Ding |
Related Documents
:
|
973053 - Ventilation, gas exchange and metabolic scaling of a sea turtle. 19025703 - Wearing an n95 respirator concurrently with a powered air-purifying respirator: effect ... 8374783 - Early monaural occlusion alters the neural map of interaural level differences in the i... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
|
Title: Current drug targets Volume: - ISSN: 1873-5592 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA. yding@med.wayne.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Current Research on Opioid Receptor Function.
Next Document: Physiological and pathological functions of acid-sensing ion channels in the central nervous system.