| Mechanisms of myocardium-coronary vessel interaction. | |
| | |
MedLine Citation:
|
PMID: 19966048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mechanisms by which the contracting myocardium exerts extravascular forces (intramyocardial pressure, IMP) on coronary blood vessels and by which it affects the coronary flow remain incompletely understood. Several myocardium-vessel interaction (MVI) mechanisms have been proposed, but none can account for all the major flow features. In the present study, we hypothesized that only a specific combination of MVI mechanisms can account for all observed coronary flow features. Three basic interaction mechanisms (time-varying elasticity, myocardial shortening-induced intracellular pressure, and ventricular cavity-induced extracellular pressure) and their combinations were analyzed based on physical principles (conservation of mass and force equilibrium) in a realistic data-based vascular network. Mechanical properties of both vessel wall and myocardium were coupled through stress analysis to simulate the response of vessels to internal blood pressure and external (myocardial) mechanical loading. Predictions of transmural dynamic vascular pressure, diameter, and flow velocity were determined under each MVI mechanism and compared with reported data. The results show that none of the three basic mechanisms alone can account for the measured data. Only the combined effect of the cavity-induced extracellular pressure and the shortening-induced intramyocyte pressure provides good agreement with the majority of measurements. These findings have important implications for elucidating the physical basis of IMP and for understanding coronary phasic flow and coronary artery and microcirculatory disease. |
| | |
Authors:
|
Dotan Algranati; Ghassan S Kassab; Yoram Lanir |
Related Documents
:
|
2246888 - Calcitonin gene-related peptide increases coronary flow and decreases coronary resistance. 8021468 - Effect of acute hypertension in the coronary circulation: role of mechanical factors an... 19363848 - From macro- to microcirculation: benefits in hypertension and diabetes. 7363298 - Modification of regional function of ischaemic myocardium by the alteration of arterial... 17414228 - Add-on amlodipine improves arterial function and structure in hypertensive patients tre... 638828 - The effect of glycopyrrolate (robinul) on the lower oesophageal sphincter. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-12-04 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 298 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-25 Completed Date: 2010-04-02 Revised Date: 2011-07-25 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H861-73 Citation Subset: IM |
Affiliation:
|
Faculty of Biomedical Engineering, Technion, Haifa, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biomechanics Blood Pressure / physiology Coronary Vessels / physiology* Elasticity / physiology Heart / physiology* Heart Rate / physiology Humans Microcirculation / physiology Models, Cardiovascular* Myocardial Contraction / physiology* Regional Blood Flow / physiology* Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
|
HL055554-11/HL/NHLBI NIH HHS; HL092048/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: REDUCED EXPRESSION OF THE SODIUM-CALCIUM EXCHANGER IN ADULT CARDIOMYOCYTES VIA ADENOVIRALLY DELIVERE...
Next Document: Progressive muscle metaboreflex activation gradually decreases spontaneous heart rate baroreflex sen...