| Mechanisms Involved in the Beneficial Effects of Spironolactone after Myocardial Infarction. | |
MedLine Citation:
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PMID: 24098808 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Our objective was to analyze the effect of spironolactone on cardiac remodeling after experimental myocardial infarction (MI), assessed by matricellular proteins levels, cardiac collagen amount and distribution, myocardial tissue metalloproteinase inhibitor-1(TIMP-1) concentration, myocyte hypertrophy, left ventricular architecture, and in vitro and in vivo cardiac function. METHODS: Wistar rats were assigned to 4 groups: control group, in which animals were submitted to simulated surgery (SHAM group; n=9); group that received spironolactone and in which animals were submitted to simulated surgery (SHAM-S group, n=9); myocardial infarction group, in which animals were submitted to coronary artery ligation (MI group, n=15); and myocardial infarction group with spironolactone supplementation (MI-S group, n=15). The rats were observed for 3 months. RESULTS: The MI group had higher values of left cardiac chambers and mass index and lower relative wall thicknesses compared with the SHAM group. In addition, diastolic and systolic functions were worse in the MI groups. However, spironolactone did not influence any of these variables. The MI-S group had a lower myocardial hydroxyproline concentration and myocyte cross-sectional area compared with the MI group. Myocardial periostin and collagen type III were lower in the MI-S group compared with the MI-group. In addition, TIMP-1 concentration in myocardium was higher in the MI-S group compared with the MI group. CONCLUSIONS: The predominant consequence of spironolactone supplementation after MI is related to reductions in collagens, with discrete attenuation of other remodeling variables. Importantly, this effect may be modulated by periostin and TIMP-1 levels. |
Authors:
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Marcos F Minicucci; Priscila P Dos Santos; Bruna P M Rafacho; Andrea F Gonçalves; Renata A C Silva; Fernanda Chiuso-Minicucci; Paula S Azevedo; Bertha F Polegato; Katashi Okoshi; Elenize J Pereira; Sergio A R Paiva; Leonardo A M Zornoff |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-9-30 |
Journal Detail:
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Title: PloS one Volume: 8 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2013 |
Date Detail:
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Created Date: 2013-10-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101285081 Medline TA: PLoS One Country: - |
Other Details:
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Languages: ENG Pagination: e76866 Citation Subset: - |
Affiliation:
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Internal Medicine Department, Botucatu Medical School, University Estadual Paulista, Botucatu, São Paulo, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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