Document Detail

Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium.
MedLine Citation:
PMID:  20353489     Owner:  NLM     Status:  MEDLINE    
One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training. Improved maximal oxygen uptake in turn is at least partly achieved because exercise training increases the ability of the myocardium to produce a greater cardiac output. In healthy subjects, this has been demonstrated repeatedly over many decades. It has recently emerged that this scenario may also be true under conditions of an initial myocardial dysfunction. For instance, myocardial improvements may still be observed after exercise training in post-myocardial infarction heart failure. In both health and disease, it is the changes that occur in the individual cardiomyocytes with respect to their ability to contract that by and large drive the exercise training-induced adaptation to the heart. Here, we review the evidence and the mechanisms by which exercise training induces beneficial changes in the mammalian myocardium, as obtained by means of experimental and clinical studies, and argue that these changes ultimately alter the function of the whole heart and contribute to the changes in whole-body function.
O J Kemi; U Wisløff
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-24
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  199     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  425-39     Citation Subset:  IM    
Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK.
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MeSH Terms
Calcium / metabolism
Excitation Contraction Coupling / physiology
Exercise / physiology*
Exercise Therapy
Heart Failure / etiology,  physiopathology
Muscle Contraction
Myocardial Contraction / physiology*
Myocardial Infarction / complications,  physiopathology,  therapy
Myocardium* / cytology,  metabolism
Myocytes, Cardiac / cytology,  physiology
Oxygen Consumption / physiology
Signal Transduction / physiology
Reg. No./Substance:

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