| Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium. | |
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MedLine Citation:
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PMID: 20353489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training. Improved maximal oxygen uptake in turn is at least partly achieved because exercise training increases the ability of the myocardium to produce a greater cardiac output. In healthy subjects, this has been demonstrated repeatedly over many decades. It has recently emerged that this scenario may also be true under conditions of an initial myocardial dysfunction. For instance, myocardial improvements may still be observed after exercise training in post-myocardial infarction heart failure. In both health and disease, it is the changes that occur in the individual cardiomyocytes with respect to their ability to contract that by and large drive the exercise training-induced adaptation to the heart. Here, we review the evidence and the mechanisms by which exercise training induces beneficial changes in the mammalian myocardium, as obtained by means of experimental and clinical studies, and argue that these changes ultimately alter the function of the whole heart and contribute to the changes in whole-body function. |
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Authors:
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O J Kemi; U Wisløff |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-24 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: 199 ISSN: 1748-1716 ISO Abbreviation: Acta Physiol (Oxf) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 425-39 Citation Subset: IM |
Affiliation:
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Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK. o.kemi@bio.gla.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Excitation Contraction Coupling / physiology Exercise / physiology* Exercise Therapy Heart Failure / etiology, physiopathology Humans Muscle Contraction Myocardial Contraction / physiology* Myocardial Infarction / complications, physiopathology, therapy Myocardium* / cytology, metabolism Myocytes, Cardiac / cytology, physiology Oxygen Consumption / physiology Signal Transduction / physiology |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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