Document Detail

Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions.
MedLine Citation:
PMID:  16341119     Owner:  NLM     Status:  MEDLINE    
Breast cancer is the most prevalent female cancer in the world and its incidence is increasing, largely because of the Western lifestyle. There is a need, not only to predict women who will develop the disease, but also to apply drug and lifestyle measures in order to prevent the disease. Current risk prediction models are based on combinations of risk factors and have good predictive but low discriminatory power. New risk prediction methods might come from examination of single nucleotide polymorphisms in several genes or from an increased knowledge of the molecular and cellular biology of the breast, particularly with respect to aberrant gene expression and protein synthesis. These methods might also determine new targets for preventive agents and lifestyle change. Many potential preventive measures are available and some have been successful. New approaches are required, however, not only to prevent the disease but to devise methods for their assessment that do not require very large and expensive clinical trials.
Anthony Howell; Andrew H Sims; Kai Ren Ong; Michelle N Harvie; D Gareth R Evans; Robert B Clarke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Oncology     Volume:  2     ISSN:  1743-4254     ISO Abbreviation:  -     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226509     Medline TA:  Nat Clin Pract Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  635-46     Citation Subset:  IM    
Dept of Medical Oncology, University of Manchester, Christie Hospital, Withington, UK.
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MeSH Terms
Anticarcinogenic Agents
Biological Markers*
Breast Neoplasms / genetics,  physiopathology*,  prevention & control*
Gene Expression Regulation, Neoplastic*
Life Style
Mass Screening
Models, Biological
Risk Assessment
Risk Factors
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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