Document Detail


Mechanisms of Disease: HCV-induced liver injury.
MedLine Citation:
PMID:  17978819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HCV persistently infects the majority of patients exposed to it and can cause irreversible fibrosis, leading to the onerous clinical sequelae of cirrhosis. In this Review, we discuss the direct effects of HCV on hepatocytes and the role of the immune system in liver damage. HCV, like many viruses, has developed methods by which to subvert host innate and adaptive immune responses to infection. HCV proteins seem to modulate apoptosis and steatosis, ultimately leading to hepatic stellate cell activation, fibrosis and hepatocellular carcinoma. In addition, HCV manipulates the immune system, disrupting both innate and adaptive immunity to establish persistent infection. The immune system initially attempts to eradicate the virus, but, in the setting of chronic infection, probably promotes hepatocyte damage and fibrosis through direct cellular toxicity and the release of inflammatory cytokines. Multiple types of cytotoxic lymphocytes, comprising the unique immune hepatic microenvironment, are likely to be important in the pathogenesis of HCV-induced liver damage. The net liver damage from HCV infection depends on the balance between the host's antiviral mechanisms and the virus' ability to subvert them.
Authors:
John A Mengshol; Lucy Golden-Mason; Hugo R Rosen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Gastroenterology & hepatology     Volume:  4     ISSN:  1743-4386     ISO Abbreviation:  -     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226510     Medline TA:  Nat Clin Pract Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  622-34     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology and Hepatology, Department of Medicine, and Integrated Program in Immunology, University of Colorado Health Sciences Center, Denver, CO 80045, USA.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Cytokines / immunology
Disease Progression
Hepatitis C, Chronic / complications*,  immunology
Hepatocytes / virology
Humans
Liver Diseases / immunology,  virology*
T-Lymphocyte Subsets / immunology
Chemical
Reg. No./Substance:
0/Cytokines

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