Document Detail


Mechanisms of defibrillation.
MedLine Citation:
PMID:  20450352     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrical shock has been the one effective treatment for ventricular fibrillation for several decades. With the advancement of electrical and optical mapping techniques, histology, and computer modeling, the mechanisms responsible for defibrillation are now coming to light. In this review, we discuss recent work that demonstrates the various mechanisms responsible for defibrillation. On the cellular level, membrane depolarization and electroporation affect defibrillation outcome. Cell bundles and collagenous septae are secondary sources and cause virtual electrodes at sites far from shocking electrodes. On the whole-heart level, shock field gradient and critical points determine whether a shock is successful or whether reentry causes initiation and continuation of fibrillation.
Authors:
Derek J Dosdall; Vladimir G Fast; Raymond E Ideker
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Annual review of biomedical engineering     Volume:  12     ISSN:  1545-4274     ISO Abbreviation:  Annu Rev Biomed Eng     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-21     Revised Date:  2014-04-25    
Medline Journal Info:
Nlm Unique ID:  100883581     Medline TA:  Annu Rev Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-58     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / physiopathology,  therapy
Dogs
Electric Countershock*
Electrodes
Electroporation
Heart / physiology,  physiopathology
Humans
Models, Cardiovascular
Rabbits
Swine
Ventricular Fibrillation / physiopathology*,  therapy*
Grant Support
ID/Acronym/Agency:
HL42760/HL/NHLBI NIH HHS; HL67748/HL/NHLBI NIH HHS; HL85370/HL/NHLBI NIH HHS; K99 HL091138-01A1/HL/NHLBI NIH HHS; K99 HL091138-02/HL/NHLBI NIH HHS; K99HL091138/HL/NHLBI NIH HHS; L30 HL082315-01/HL/NHLBI NIH HHS; R00 HL091138/HL/NHLBI NIH HHS; R00 HL091138-03/HL/NHLBI NIH HHS; R00 HL091138-04/HL/NHLBI NIH HHS; R01 HL085370-06/HL/NHLBI NIH HHS
Comments/Corrections

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