Document Detail

Mechanisms and clinical consequences of vascular calcification.
MedLine Citation:
PMID:  22888324     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Vascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events, including myocardial infarction and stroke. Previously vascular calcification was thought to be a passive process which involved the deposition of calcium and phosphate in arteries and cardiac valves. However, recent studies have shown that vascular calcification is a highly regulated, cell-mediated process similar to bone formation. In this article, we outline the current understanding of key mechanisms governing vascular calcification and highlight the clinical consequences. By understanding better the molecular pathways and genetic circuitry responsible for the pathological mineralization process novel drug targets may be identified and exploited to combat and reduce the detrimental effects of vascular calcification on human health.
Dongxing Zhu; Neil C W Mackenzie; Colin Farquharson; Vicky E Macrae
Related Documents :
3409914 - Haemodynamic effects of intravenous isosorbide-5-mononitrate in acute and chronic left ...
22105784 - Value of electrocardiogram in the differentiation of hypertensive heart disease, hypert...
7038484 - Changes in the use of medical technologies, 1972-1977: a study of 10 inpatient diagnoses.
19668244 - Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms.
3233804 - Quantitation of myocardial fibrosis and its relation to function in essential hypertens...
22408024 - Slackness between vessel and myocardium is necessary for coronary flow reserve.
Publication Detail:
Type:  Journal Article     Date:  2012-08-06
Journal Detail:
Title:  Frontiers in endocrinology     Volume:  3     ISSN:  1664-2392     ISO Abbreviation:  Front Endocrinol (Lausanne)     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-13     Completed Date:  2012-08-23     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  101555782     Medline TA:  Front Endocrinol (Lausanne)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  95     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Grant Support
20413//Arthritis Research UK; BB/F023928/1//Biotechnology and Biological Sciences Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Social psychological origins of conspiracy theories: the case of the jewish conspiracy theory in mal...
Next Document:  Glutamate signaling in bone.