Document Detail


Mechanisms of chromosomal instability.
MedLine Citation:
PMID:  20334839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by increasing genetic diversity among tumor cells. Here, we review the mechanisms underlying CIN, which include defects in chromosome cohesion, mitotic checkpoint function, centrosome copy number, kinetochore-microtubule attachment dynamics, and cell-cycle regulation. Understanding these mechanisms provides insight into the cellular consequences of CIN and reveals the possibility of exploiting CIN in cancer therapy.
Authors:
Sarah L Thompson; Samuel F Bakhoum; Duane A Compton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current biology : CB     Volume:  20     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-07-02     Revised Date:  2013-10-24    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  R285-95     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy
Animals
Cell Cycle / genetics
Centrosome / physiology
Chromosomal Instability*
Chromosome Segregation / genetics
Humans
Kinetochores / physiology
Microtubules / genetics
Mitosis / genetics
Mitotic Spindle Apparatus / genetics
Models, Genetic
Neoplasms / genetics*,  pathology
Saccharomyces cerevisiae / genetics
Grant Support
ID/Acronym/Agency:
GM51542/GM/NIGMS NIH HHS; P30 CA023108/CA/NCI NIH HHS; R01 GM051542/GM/NIGMS NIH HHS
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