Document Detail

Mechanisms of Cell Propulsion by Active Stresses.
MedLine Citation:
PMID:  21804763     Owner:  NLM     Status:  Publisher    
The mechanisms by which cytoskeletal flows and cell-substrate interactions interact to generate cell motion are explored using a simplified model of the cytoskeleton as a viscous gel containing active stresses. This model yields explicit general results relating cell speed and traction forces to the distributions of active stress and cell-substrate friction. It is found that 1) the cell velocity is given by a function that quantifies the asymmetry of the active-stress distribution, 2) gradients in cell-substrate friction can induce motion even when the active stresses are symmetrically distributed, 3) the traction-force dipole is enhanced by protrusive stresses near the cell edges or contractile stresses near the center of the cell, and 4) the cell velocity depends biphasically on the cell-substrate adhesion strength if active stress is enhanced by adhesion. Specific experimental tests of the calculated dependences are proposed.
A E Carlsson
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Publication Detail:
Journal Detail:
Title:  New journal of physics     Volume:  13     ISSN:  1367-2630     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101314392     Medline TA:  New J Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Physics, Washington University, Campus Box 1105, One Brookings Drive, St. Louis, MO. 63130, U.S.A.
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Grant Support
R01 GM086882-04//NIGMS NIH HHS

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