| Mechanisms of Cell Propulsion by Active Stresses. | |
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MedLine Citation:
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PMID: 21804763 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The mechanisms by which cytoskeletal flows and cell-substrate interactions interact to generate cell motion are explored using a simplified model of the cytoskeleton as a viscous gel containing active stresses. This model yields explicit general results relating cell speed and traction forces to the distributions of active stress and cell-substrate friction. It is found that 1) the cell velocity is given by a function that quantifies the asymmetry of the active-stress distribution, 2) gradients in cell-substrate friction can induce motion even when the active stresses are symmetrically distributed, 3) the traction-force dipole is enhanced by protrusive stresses near the cell edges or contractile stresses near the center of the cell, and 4) the cell velocity depends biphasically on the cell-substrate adhesion strength if active stress is enhanced by adhesion. Specific experimental tests of the calculated dependences are proposed. |
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Authors:
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A E Carlsson |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: New journal of physics Volume: 13 ISSN: 1367-2630 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101314392 Medline TA: New J Phys Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Physics, Washington University, Campus Box 1105, One Brookings Drive, St. Louis, MO. 63130, U.S.A. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 GM086882-04//NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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