| Mechanisms of cadmium-induced proximal tubule injury: new insights with implications for biomonitoring and therapeutic interventions. | |
| | |
MedLine Citation:
|
PMID: 22669569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cadmium is an important industrial agent and environmental pollutant that is a major cause of kidney disease. With chronic exposure, cadmium accumulates in the epithelial cells of the proximal tubule, resulting in a generalized reabsorptive dysfunction characterized by polyuria and low-molecular-weight proteinuria. The traditional view has been that as cadmium accumulates in proximal tubule cells, it produces a variety of relatively nonspecific toxic effects that result in the death of renal epithelial cells through necrotic or apoptotic mechanisms. However, a growing volume of evidence suggests that rather than merely being a consequence of cell death, the early stages of cadmium-induced proximal tubule injury may involve much more specific changes in cell-cell adhesion, cellular signaling pathways, and autophagic responses that occur well before the onset of necrosis or apoptosis. In this commentary, we summarize these recent findings, and we offer our own perspectives as to how they relate to the toxic actions of cadmium in the kidney. In addition, we highlight recent findings, suggesting that it may be possible to detect the early stages of cadmium toxicity through the use of improved biomarkers. Finally, some of the therapeutic implications of these findings will be considered. Because cadmium is, in many respects, a model cumulative nephrotoxicant, these insights may have broader implications regarding the general mechanisms through which a variety of drugs and toxic chemicals damage the kidney. |
| | |
Authors:
|
Walter C Prozialeck; Joshua R Edwards |
Related Documents
:
|
12393019 - Mrna localization in plants: targeting to the cell's cortical region and beyond. 21242969 - P2x(7) receptor activation enhances sk3 channels- and cystein cathepsin-dependent cance... 21239349 - The flower code and cancer development. 19454179 - Microarray analysis using a limited amount of cells. 3021099 - Primary isolation and identification of avian rotaviruses from turkeys exhibiting signs... 22727809 - Protection of exenatide for retinal ganglion cells with different glucose concentrations. 9236239 - Pattern formation in the basilar papilla: evidence for cell rearrangement. 21858029 - Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reper... 8577399 - 5,7-dihydroxytryptamine uptake discriminates living serotonergic cells from dopaminergi... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-06-05 |
Journal Detail:
|
Title: The Journal of pharmacology and experimental therapeutics Volume: 343 ISSN: 1521-0103 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-09-17 Completed Date: 2012-11-26 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 2-12 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA. wprozi@midwestern.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Kidney Injury
/
chemically induced*,
metabolism*,
pathology Animals Apoptosis / drug effects, physiology Biological Markers / metabolism Cadmium / metabolism Cadmium Poisoning / metabolism*, pathology Cell Adhesion / drug effects, physiology Environmental Pollutants / toxicity Humans Kidney Tubules, Proximal / drug effects*, metabolism*, pathology |
| Grant Support | |
ID/Acronym/Agency:
|
R01-ES006478/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Environmental Pollutants; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reduced frequency of NKT-like cells in patients with progressive chronic lymphocytic leukemia.
Next Document: The minimal impact of food on the pharmacokinetics of ridaforolimus.