Document Detail


Mechanism of stress ulcer. Influence of alpha-adrenergic blockade on stress ulceration and gastric mucosal energy metabolism.
MedLine Citation:
PMID:  677104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In previous reports from this laboratory, it has been proposed that stress ulceration results from a severe gastric mucosal energy deficit due to shock-induced mucosal ischemia. In the experiments described in this report, the hypothesis was further tested by studying stress ulceration and gastric mucosal energy metabolism in rabbits subjected to hemorrhagic shock with or without the concomitant administration of an alpha-adrenergic blocking agent. Our data show that stress ulceration and gastric mucosal energy deficits are significantly less severe when shock is combined with alpha-adrenergic blockade.
Authors:
R Menguy; Y F Masters
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of digestive diseases     Volume:  23     ISSN:  0002-9211     ISO Abbreviation:  Am J Dig Dis     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404011     Medline TA:  Am J Dig Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  493-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Energy Metabolism / drug effects*
Gastric Mucosa / metabolism*
Male
Phentolamine / pharmacology*
Rabbits
Shock, Hemorrhagic / complications,  metabolism
Stomach Ulcer / metabolism*,  pathology
Chemical
Reg. No./Substance:
50-60-2/Phentolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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