| Mechanism of stress ulcer. Influence of alpha-adrenergic blockade on stress ulceration and gastric mucosal energy metabolism. | |
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MedLine Citation:
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PMID: 677104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In previous reports from this laboratory, it has been proposed that stress ulceration results from a severe gastric mucosal energy deficit due to shock-induced mucosal ischemia. In the experiments described in this report, the hypothesis was further tested by studying stress ulceration and gastric mucosal energy metabolism in rabbits subjected to hemorrhagic shock with or without the concomitant administration of an alpha-adrenergic blocking agent. Our data show that stress ulceration and gastric mucosal energy deficits are significantly less severe when shock is combined with alpha-adrenergic blockade. |
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Authors:
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R Menguy; Y F Masters |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of digestive diseases Volume: 23 ISSN: 0002-9211 ISO Abbreviation: Am J Dig Dis Publication Date: 1978 Jun |
Date Detail:
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Created Date: 1978-09-25 Completed Date: 1978-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404011 Medline TA: Am J Dig Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 493-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Energy Metabolism / drug effects* Gastric Mucosa / metabolism* Male Phentolamine / pharmacology* Rabbits Shock, Hemorrhagic / complications, metabolism Stomach Ulcer / metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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50-60-2/Phentolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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