Document Detail

Mechanism responsible for the cardiovascular depressant. Effect of protamine sulfate.
MedLine Citation:
PMID:  4842984     Owner:  NLM     Status:  MEDLINE    
The mechanism of protamine-induced hypotension and bradycardia was investigated in anesthetized, heparinized dogs. Several groups of animals with intact circulation were studied for their responses to protamine under control conditions and following the administration of various pharmacological agents. The parameters observed include femoral arterial pressure (FAP), central venous pressure (CVP), left ventricular pressure (LVP) and its rate of rise (dp/dt), left ventricular contractile element velocity of shortening (Vce), maximal Vce (V max) and cardiac output (CO). Various groups were studied under the following pharmacological conditions: autonomic cholinergic blockade by atropine; alpha and beta adrenergic receptor blockade using phenoxybenzamine and propranolol respectively; ganglionic and adrenal medullary block using hexamethonium, and depletion of endogenous histamine by means of compound 48/80. Another group was placed on total cardiopulmonary bypass thus isolating the heart from the peripheral circulation. The effect of protamine on the vascular tree alone was then observed by monitoring FAP before and after protamine administration. The findings indicate that the cardiovascular effects of protamine are produced by a direct effect on the myocardium and vascular tree.
M A Fadali; M Ledbetter; C A Papacostas; L J Duke; G M Lemole
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of surgery     Volume:  180     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1974 Aug 
Date Detail:
Created Date:  1974-09-19     Completed Date:  1974-09-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-5     Citation Subset:  AIM; IM    
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MeSH Terms
Atropine / pharmacology
Blood Pressure / drug effects
Bradycardia / chemically induced
Cardiac Output / drug effects
Central Venous Pressure / drug effects
Extracorporeal Circulation
Heart / drug effects*
Heart Ventricles / drug effects
Heparin / pharmacology
Hexamethonium Compounds / pharmacology
Hypotension / chemically induced
Phenoxybenzamine / pharmacology
Propranolol / pharmacology
Protamines / adverse effects,  pharmacology*
Ventricular Function
p-Methoxy-N-methylphenethylamine / pharmacology
Reg. No./Substance:
0/Hexamethonium Compounds; 0/Protamines; 4091-50-3/p-Methoxy-N-methylphenethylamine; 51-55-8/Atropine; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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