Document Detail

Mechanism of recovery in esophageal epithelia of rats with severe zinc deficiency.
MedLine Citation:
PMID:  7732747     Owner:  NLM     Status:  MEDLINE    
Forty-six rats fed a Zn-deficient diet for 18 days, were divided into three groups and treated with Zn-deficient diet (GI), a normal (Zn-adequate) diet (GII) or a pharmacological Zn therapy diet (GIII) for 3 days. For light and electron microscopy, samples were taken at times 0, 8, 12, 24 and 72 h after treatment. In treatment GI, at all times, all rats had esophageal parakeratosis. With treatment GII, there was a variable progression toward normalization of the epithelium at 12 and 24 h. At 72 h there was almost complete recovery of normal epithelium. In treatment GIII at 8 h, large, light cells in the basal layer were shown to be present between dark cylindrical cells, a finding which was transitionary and disappeared at 12 h. Also, a thin keratinized layer was observed above the granular layer at 12 h. Recovery had progressed at 24 h and was complete after 72 h. The results are discussed in terms of a potential role of Zn in the sequence of cytochemical events in epithelial differentiation.
M Rezaian; S Yamashiro; M H Hardy; W J Bettger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Veterinärmedizin. Reihe A     Volume:  41     ISSN:  0514-7158     ISO Abbreviation:  Zentralbl Veterinarmed A     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-06-01     Completed Date:  1995-06-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331323     Medline TA:  Zentralbl Veterinarmed A     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  690-9     Citation Subset:  IM    
University of Guelph, Ontario Veterinary College, Department of Biomedical Sciences, Ontario, Canada.
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MeSH Terms
Animal Feed / analysis
Epithelium / physiology,  ultrastructure
Esophagus / physiology*,  ultrastructure
Microscopy, Electron
Rats, Wistar
Time Factors
Zinc / analysis,  deficiency*
Reg. No./Substance:

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