Document Detail


Mechanism of recovery in esophageal epithelia of rats with severe zinc deficiency.
MedLine Citation:
PMID:  7732747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-six rats fed a Zn-deficient diet for 18 days, were divided into three groups and treated with Zn-deficient diet (GI), a normal (Zn-adequate) diet (GII) or a pharmacological Zn therapy diet (GIII) for 3 days. For light and electron microscopy, samples were taken at times 0, 8, 12, 24 and 72 h after treatment. In treatment GI, at all times, all rats had esophageal parakeratosis. With treatment GII, there was a variable progression toward normalization of the epithelium at 12 and 24 h. At 72 h there was almost complete recovery of normal epithelium. In treatment GIII at 8 h, large, light cells in the basal layer were shown to be present between dark cylindrical cells, a finding which was transitionary and disappeared at 12 h. Also, a thin keratinized layer was observed above the granular layer at 12 h. Recovery had progressed at 24 h and was complete after 72 h. The results are discussed in terms of a potential role of Zn in the sequence of cytochemical events in epithelial differentiation.
Authors:
M Rezaian; S Yamashiro; M H Hardy; W J Bettger
Related Documents :
17618107 - Moderate zinc restriction affects intestinal health and immune function in lipopolysacc...
3719907 - Enhancement of methylbenzylnitrosamine-induced esophageal carcinogenesis in zinc-defici...
13979317 - Antagonistic relationship between dietary cadmium and zinc.
6349457 - Zinc and the special senses.
7616327 - Lipid peroxidation and 8-hydroxydeoxyguanosine formation in rats fed fish oil with diff...
8068007 - Application of simultaneous spleen and liver perfusion to the study of reverse choleste...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Veterinärmedizin. Reihe A     Volume:  41     ISSN:  0514-7158     ISO Abbreviation:  Zentralbl Veterinarmed A     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-06-01     Completed Date:  1995-06-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331323     Medline TA:  Zentralbl Veterinarmed A     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  690-9     Citation Subset:  IM    
Affiliation:
University of Guelph, Ontario Veterinary College, Department of Biomedical Sciences, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animal Feed / analysis
Animals
Epithelium / physiology,  ultrastructure
Esophagus / physiology*,  ultrastructure
Male
Microscopy, Electron
Rats
Rats, Wistar
Time Factors
Zinc / analysis,  deficiency*
Chemical
Reg. No./Substance:
7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of verapamil, sodium nitroprusside, tetrodotoxin and caffeine on the electrical transmural s...
Next Document:  Sevoflurane and oxygen anaesthesia following administration of atropine-xylazine-guaifenesin-thiopen...