| Mechanism of proteinuria in nephrotic syndrome. | |
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MedLine Citation:
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PMID: 1485544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We developed a "tissue negative staining method" to observe the molecular-level ultrastructure in situ in any portion of the ultrathin sections routinely prepared for electron microscopy. This method was used in electron microscopy of the glomerular basement membranes (GBM). The GBM in patients with nephrotic syndrome was discovered to possess a tunnel structure, designated as "nephrotic tunnel", with lumen large enough to allow free passage of protein molecules. This tunnel seemed to be involved in the etiology of nephrotic syndrome. This new method appears to be applicable to a variety of purposes in biological studies. |
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Authors:
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Z Ota; K Shikata; K Ota |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta medica Okayama Volume: 46 ISSN: 0386-300X ISO Abbreviation: Acta Med. Okayama Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-02-18 Completed Date: 1993-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417611 Medline TA: Acta Med Okayama Country: JAPAN |
Other Details:
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Languages: eng Pagination: 483-7 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Okayama University Medical School, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basement Membrane / ultrastructure Cattle Descemet Membrane / ultrastructure Humans Kidney Glomerulus / ultrastructure* Nephrotic Syndrome / complications*, pathology Proteinuria / etiology*, pathology* Reference Values |
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