Document Detail

Mechanism of posturally induced crackles as predictor of latent congestive heart failure.
MedLine Citation:
PMID:  9311049     Owner:  NLM     Status:  MEDLINE    
We investigated the role of changes in pulmonary function in posturally induced crackles (PIC) in 76 patients with various heart diseases. Regional ventilation was evaluated by spirometric gated ventilation scanning using 133Xe in 23 of these patients and its relationship to PIC was analyzed. A change from the sitting to the supine position was associated with a significant decrease in the percent functional residual capacity (FRC, p < 0.01) and significant increases in closing volume (CV), CV/vital capacity (VC) and closing capacity (CC)/FRC (p < 0.01) in the PIC-positive subjects. CV, CV/VC and CC/FRC did not differ significantly between PIC-positive (n = 37) and PIC-negative (n = 39) subjects in the sitting position, but in the supine position, these values were significantly higher in the PIC-positive group than in the PIC-negative group (CV: p < 0.05, CV/VC and CC/FRC: p < 0.01). These results suggest that airway closure was markedly increased in PIC-positive subjects in the supine position compared with PIC-negative subjects. Regional ventilation (V) was assessed in the sitting and the supine position from right lateral images divided into 9 segments from the base to the apex of the lung using spirometric gated ventilation scanning. There was no significant difference in regional ventilation in the sitting position between PIC-negative (n = 11) and PIC-positive (n = 12) subjects; in the supine position, regional ventilation decreased significantly at the base in the PIC-positive group. Findings suggest that PIC at the base of the lungs may be related to airway closure at the base of the lungs in the supine position in PIC-positive subjects.
N Yasuda; K Gotoh; Y Yagi; K Nagashima; T Sawa; M Nomura; S Hirakawa; H Fujiwara
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  64     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1997  
Date Detail:
Created Date:  1997-11-13     Completed Date:  1997-11-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  336-41     Citation Subset:  IM    
Second Department of Internal Medicine, Gifu University School of Medicine, Japan.
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MeSH Terms
Analysis of Variance
Heart Failure / diagnosis*
Lung / radionuclide imaging
Lung Volume Measurements
Middle Aged
Predictive Value of Tests
Pulmonary Ventilation
Reproducibility of Results
Respiratory Function Tests
Respiratory Sounds*
Sensitivity and Specificity
Total Lung Capacity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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