| Mechanism of pharmacodynamic and pharmacokinetic interactions between acetohexamide and phenylbutazone in rabbits. | |
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MedLine Citation:
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PMID: 2096386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interaction of acetohexamide (AH) with phenylbutazone (PBZ) was investigated in rabbits. Orally administered PBZ caused a potentiation of hypoglycaemic action after oral administration of AH. This can be explained by the fact that the co-administration of PBZ significantly increased both the serum concentrations of AH and its pharmacologically active metabolite. (-)-hydroxyhexamide [(-)-HH], after AH administration. The co-administration of PBZ decreased the renal clearance (Clr) and non-renal clearance (Clnr) of AH. PBZ inhibited the in vitro reduction of AH to (-)-HH and decreased the accumulation of (-)-HH by the kidney cortical slices. These results indicate that the mechanism of in vivo interaction of AH with PBZ is complicated. |
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Authors:
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Y Imamura; T Nomura; Y Katsuki; Y Kojima; M Otagiri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology & toxicology Volume: 67 ISSN: 0901-9928 ISO Abbreviation: Pharmacol. Toxicol. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-07-17 Completed Date: 1991-07-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8702180 Medline TA: Pharmacol Toxicol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 415-9 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, Kumamoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetohexamide
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administration & dosage,
pharmacokinetics,
pharmacology* Administration, Oral Animals Blood Glucose / metabolism Blood Proteins / metabolism Drug Interactions Hypoglycemia / drug therapy Kidney Cortex / anatomy & histology, metabolism Male Oxidation-Reduction Phenylbutazone / administration & dosage, pharmacokinetics, pharmacology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Blood Proteins; 50-33-9/Phenylbutazone; 968-81-0/Acetohexamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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