| Mechanism of parturition and preterm labor. | |
| | |
MedLine Citation:
|
PMID: 11023206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Preterm birth occurs in 5 to 10 percent of all pregnancies and accounts for 75 percent of neonatal mortality and morbidity, including long-term handicap. Thirty percent of preterm birth may be associated with an underlying infective process, and approximately 50 percent are idiopathic. Preterm birth corresponds to a syndrome with a variety of causes. The factors contributing to preterm birth may vary at different "windows" of gestation. Glucocorticoids seem to have a central role in processes of birth at term and preterm, and alter synthesis and/or activity of key enzymes in prostaglandin synthesis and metabolism as well as increasing corticotropin-releasing hormone output by intrauterine tissues. This new information should facilitate development of improved methods of diagnosis and therapy for patients at risk of preterm labor. TARGET AUDIENCE: Gynecologists and Family Physicians LEARNING OBJECTIVES: After completion of this article, the reader will be able to describe potential mechanisms of partition and preterm labor and to list the various substances that can inhibit and promote myometrial contractions. |
| | |
Authors:
|
Challis JRG |
Related Documents
:
|
12112946 - Bacterial vaginosis and other asymptomatic vaginal infections in pregnancy. 17074546 - Association of maternal il-1 receptor antagonist intron 2 gene polymorphism and preterm... 12015526 - The preterm prediction study: the value of serum alkaline phosphatase, alpha-fetoprotei... 15172846 - Perinatal outcome among singleton infants conceived through assisted reproductive techn... 21288736 - Cord blood chemokines differentiate between spontaneous and elective preterm births in ... 11006206 - Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating feta... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Obstetrical & gynecological survey Volume: 55 ISSN: 0029-7828 ISO Abbreviation: Obstet Gynecol Surv Publication Date: 2000 Oct |
Date Detail:
|
Created Date: 2001-01-08 Completed Date: 2001-01-25 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0401007 Medline TA: Obstet Gynecol Surv Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 650-60 Citation Subset: IM |
Affiliation:
|
Department of Physiology, University of Toronto, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada. j.challis@utoronto.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Glucocorticoids / adverse effects Humans Labor, Obstetric / physiology* Myometrium / physiology Obstetric Labor, Premature / etiology*, physiopathology, therapy Pregnancy Prostaglandins / pharmacology* Risk Factors Uterine Contraction / physiology* Uterus / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Glucocorticoids; 0/Prostaglandins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Müllerian agenesis: etiology, diagnosis, and management.
Next Document: A review of the potential and versatility of colloidal gold cytochemical labeling for molecular morp...