Document Detail


Mechanism of ocular hypotensive action of bimatoprost (Lumigan) in patients with ocular hypertension or glaucoma.
MedLine Citation:
PMID:  15350319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine the mechanism of ocular hypotensive action of bimatoprost in patients with ocular hypertension or glaucoma. DESIGN: Double-masked, placebo-controlled, randomized, paired comparison crossover study of the effect of bimatoprost on aqueous humor dynamics. PARTICIPANTS AND CONTROLS: Twenty-nine patients with ocular hypertension or glaucoma. METHODS: Bimatoprost and a placebo were administered once a day, in the evening, for 7 days before assessment of aqueous dynamics using tonometry, Schiötz tonography, and fluorophotometry. Intraocular pressure (IOP) response to water drinking was measured. MAIN OUTCOME MEASURES: Aqueous humor flow rate, outflow facility, and IOP. RESULTS: Intraocular pressure was lowered 29% in the morning and 33% at noon by bimatoprost. Aqueous humor flow was unchanged. Tonographic facility of outflow was increased 47% by bimatoprost relative to the placebo. Assuming an extraocular pressure of 8 mmHg and that extraocular pressure is not altered by bimatoprost, the calculated rate of pressure-insensitive outflow was increased 95% by bimatoprost. During the first hour after water drinking, bimatoprost dampened the IOP rise. CONCLUSION: As was seen in healthy normal eyes, bimatoprost increased both the pressure-sensitive and the pressure-insensitive outflows of aqueous humor in patients with ocular hypertension or glaucoma. Bimatoprost had no significant effect on aqueous humor formation.
Authors:
Gregory A Christiansen; Cherie B Nau; Jay W McLaren; Douglas H Johnson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ophthalmology     Volume:  111     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2004-09-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1658-62     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amides
Antihypertensive Agents / administration & dosage,  pharmacology*
Aqueous Humor / drug effects*,  secretion
Cloprostenol / analogs & derivatives
Cross-Over Studies
Double-Blind Method
Female
Fluorophotometry
Glaucoma / drug therapy*,  metabolism
Humans
Intraocular Pressure / drug effects*
Lipids / administration & dosage,  pharmacology*
Male
Middle Aged
Ocular Hypertension / drug therapy,  metabolism
Ophthalmic Solutions / administration & dosage,  pharmacology
Tonometry, Ocular
Chemical
Reg. No./Substance:
0/Amides; 0/Antihypertensive Agents; 0/Lipids; 0/Ophthalmic Solutions; 0/bimatoprost; 40665-92-7/Cloprostenol
Comments/Corrections
Comment In:
Ophthalmology. 2005 Aug;112(8):1478; author reply 1479   [PMID:  16061098 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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