Document Detail

Mechanism of occupational asthma due to western red cedar (Thuja plicata).
MedLine Citation:
PMID:  8116639     Owner:  NLM     Status:  MEDLINE    
Occupational asthma due to Western red cedar is the most common form of occupational asthma in the Pacific Northwest and affects 4-13.5% of the exposed population. It has been shown to be caused by plicatic acid, a low molecular weight compound present uniquely in the wood. The mechanism of asthma induced by plicatic acid is not known, as specific IgG antibodies were found only in about 20% of patients. Sera from patients with red cedar asthma failed to passively sensitize human lung fragments of human basophils. Basophils from patients with this disease released histamine when challenged directly with plicatic acid in a specific manner. Immunologic mechanisms other than Type I hypersensitivity reaction are likely to be involved.
M Chan-Yeung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  25     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-03-28     Completed Date:  1994-03-28     Revised Date:  2006-04-19    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
University of British Columbia, Department of Medicine, Vancouver General Hospital, Canada.
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MeSH Terms
Allergens / adverse effects*,  immunology
Antibodies, Anti-Idiotypic
Asthma / etiology*,  immunology
Dust / adverse effects*
Immunoglobulin E / immunology
Naphthols / adverse effects*,  immunology
Occupational Diseases / etiology*,  immunology
Reg. No./Substance:
0/Allergens; 0/Antibodies, Anti-Idiotypic; 0/Dust; 0/Lignans; 0/Naphthols; 16462-65-0/plicatic acid; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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