| Mechanism of occupational asthma due to western red cedar (Thuja plicata). | |
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MedLine Citation:
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PMID: 8116639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Occupational asthma due to Western red cedar is the most common form of occupational asthma in the Pacific Northwest and affects 4-13.5% of the exposed population. It has been shown to be caused by plicatic acid, a low molecular weight compound present uniquely in the wood. The mechanism of asthma induced by plicatic acid is not known, as specific IgG antibodies were found only in about 20% of patients. Sera from patients with red cedar asthma failed to passively sensitize human lung fragments of human basophils. Basophils from patients with this disease released histamine when challenged directly with plicatic acid in a specific manner. Immunologic mechanisms other than Type I hypersensitivity reaction are likely to be involved. |
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Authors:
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M Chan-Yeung |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of industrial medicine Volume: 25 ISSN: 0271-3586 ISO Abbreviation: Am. J. Ind. Med. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-03-28 Completed Date: 1994-03-28 Revised Date: 2006-04-19 |
Medline Journal Info:
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Nlm Unique ID: 8101110 Medline TA: Am J Ind Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 13-8 Citation Subset: IM |
Affiliation:
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University of British Columbia, Department of Medicine, Vancouver General Hospital, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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adverse effects*,
immunology Animals Antibodies, Anti-Idiotypic Asthma / etiology*, immunology Dust / adverse effects* Humans Immunoglobulin E / immunology Lignans* Naphthols / adverse effects*, immunology Occupational Diseases / etiology*, immunology Trees Wood* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antibodies, Anti-Idiotypic; 0/Dust; 0/Lignans; 0/Naphthols; 16462-65-0/plicatic acid; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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