| Mechanism for myocardial localization and rapid liver clearance of Tc-99m-N-MPO: a new perfusion radiotracer for heart imaging. | |
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MedLine Citation:
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PMID: 19288164 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: [Tc-99m-N(mpo)(PNP5)](+) (Tc-99m-N-MPO: Hmpo = 2-mercaptopyridine N-oxide and PNP5 = N-ethoxyethyl-N,N-bis[2-(bis(3-methoxypropyl)phosphino)ethyl]amine) is a new Tc-99m radiotracer useful for myocardial perfusion imaging. The main objective of this study is to elucidate the mechanism for myocardial localization and fast liver clearance of Tc-99m-N-MPO in comparison with Tc-99m-sestamibi ([Tc-99m-(MIBI)(6)](+): MIBI = 2-methoxy-2-methylpropylisonitrile). METHODS AND RESULTS: Subcellular distribution of Tc-99m-N-MPO and Tc-99m-sestamibi was examined in the excised Sprague-Dawley (SD) rat myocardium. Biodistribution and planar imaging studies were performed using SD rats in the absence/presence of Cyclosporin-A. Due to negative plasma and mitochondrial potentials, 84.5% +/- 3.2% of Tc-99m-N-MPO was found in the mitochondrial fraction as compared to 88.0% +/- 1.5% of Tc-99m-sestamibi. There was no significant difference in their mitochondrial accumulation. Tc-99m-N-MPO was also able to retain its chemical integrity in rat myocardium. Pre-treatment of SD rats with Cys-A result in significant increase in the kidney and liver uptake of Tc-99m-N-MPO. CONCLUSION: Tc-99m-N-MPO and Tc-99m-sestamibi share almost identical subcellular distribution and localization mechanism. The MDR transport function of hepatocytes and renal cells is responsible for the fast clearance kinetics of Tc-99m-N-MPO from liver and kidneys, respectively. Tc-99m-N-MPO is a very promising myocardial perfusion radiotracer with favorable biodistribution properties and rapid liver clearance. |
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Authors:
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Young-Seung Kim; Jiyun Shi; Shizhen Zhai; Guihua Hou; Shuang Liu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-03-14 |
Journal Detail:
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Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 16 ISSN: 1532-6551 ISO Abbreviation: J Nucl Cardiol Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-07-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 571-9 Citation Subset: IM |
Affiliation:
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School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 CA115883 A2/CA/NCI NIH HHS; R21 EB003419-02/EB/NIBIB NIH HHS; R21 HL083961-01/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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J Nucl Cardiol. 2009 Jul-Aug;16(4):493-6
[PMID:
19408065
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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