| Mechanism of lymphoma cell death induced by cyclic AMP. | |
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MedLine Citation:
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PMID: 170834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A mouse lymphoma tissue culture line, S49, is killed by isoproterenol, choleratoxin, or prostaglandin E1, inducers of cyclic AMP (cAMP) in these cells, or by the analog dibutyryl (db) cAMP. Cell death follows arrest in the G1 phase of the cell cycle. Mutant subclones obtained by growing S49 with dbcAMP were resistant to killing. They were deficient in cAMP-dependent protein kinase. These results are discussed in relation to the possible physiologic role of cAMP-induced cell death in T-cell differentiation. |
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Authors:
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P Coffino; H R Bourne; G M Tomkins |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of pathology Volume: 81 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1975 Oct |
Date Detail:
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Created Date: 1975-12-29 Completed Date: 1975-12-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bucladesine / pharmacology Cell Division Cell Line Cell Survival Cells, Cultured / drug effects Cholera Cyclic AMP / pharmacology* Isoproterenol / pharmacology Kinetics Lymphoma* Mice Mutation Prostaglandins E / pharmacology Protein Kinases / metabolism T-Lymphocytes / drug effects Toxins, Biological / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 0/Toxins, Biological; 362-74-3/Bucladesine; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol; EC 2.7.-/Protein Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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