Document Detail


Mechanism of lumen gain with a novel rotational aspiration atherectomy system for peripheral arterial disease: examination by intravascular ultrasound.
MedLine Citation:
PMID:  20599165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to evaluate the mechanism of luminal gain with a novel atheroablation system (Pathway PV) for the treatment of peripheral artery disease using intravascular ultrasound (IVUS). METHODS: The atherectomy system is a rotational atherectomy device, which employs expandable rotating blades with ports that allow flushing and aspiration of the plaque material or thrombus. In this first-in-man clinical study, IVUS analysis was available in 6 patients with lower limb ischemia treated with this device. The treatment results were assessed using IVUS at pre and post atherectomy. Lumen beyond burr size (LBB) was defined as lumen gain divided by the estimated burr area determined by the burr-size. RESULTS: IVUS analysis was available in six patients (superficial femoral artery n=3, popliteal artery n=2, posterior tibial artery n=1). Atheroablation achieved a significant increase in lumen area (LA) (preintervention 3.9+/-0.4, postatheroablation 8.0+/-1.7 mm(2), P<.05), and significant reduction in plaque area (27.5+/-4.0, 23.7+/-3.1 mm(2), P=.001), while there was no change in the vessel area (31.3+/-4.2, 32.1+/-2.8 mm(2), P=.4). LBB was 57.4+/-51.3%. CONCLUSION: This novel rotational aspiration atherectomy device achieved significant luminal gain by debulking in the absence of vessel stretching. The LA was greater than burr-sized lumen expectancy at cross-sections along the treated segments, suggesting a complimentary role of aspiration in luminal gain in atherosclerotic peripheral artery lesions.
Authors:
Ali H M Hassan; Junya Ako; Katsuhisa Waseda; Yasuhiro Honda; Thomas Zeller; Martin B Leon; Peter J Fitzgerald
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Cardiovascular revascularization medicine : including molecular interventions     Volume:  11     ISSN:  1878-0938     ISO Abbreviation:  Cardiovasc Revasc Med     Publication Date:    2010 Jul-Sep
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101238551     Medline TA:  Cardiovasc Revasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Affiliation:
Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, CA 94305-5637, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Atherectomy / instrumentation*,  methods
Atherectomy, Coronary / instrumentation,  methods
Chi-Square Distribution
Equipment Design
Equipment Safety
Female
Follow-Up Studies
Humans
Male
Peripheral Vascular Diseases / therapy*,  ultrasonography*
Prospective Studies
Risk Assessment
Severity of Illness Index
Survival Rate
Treatment Outcome
Ultrasonography, Interventional*
Vascular Patency / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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