| Mechanism of lumen gain with a novel rotational aspiration atherectomy system for peripheral arterial disease: examination by intravascular ultrasound. | |
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MedLine Citation:
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PMID: 20599165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate the mechanism of luminal gain with a novel atheroablation system (Pathway PV) for the treatment of peripheral artery disease using intravascular ultrasound (IVUS). METHODS: The atherectomy system is a rotational atherectomy device, which employs expandable rotating blades with ports that allow flushing and aspiration of the plaque material or thrombus. In this first-in-man clinical study, IVUS analysis was available in 6 patients with lower limb ischemia treated with this device. The treatment results were assessed using IVUS at pre and post atherectomy. Lumen beyond burr size (LBB) was defined as lumen gain divided by the estimated burr area determined by the burr-size. RESULTS: IVUS analysis was available in six patients (superficial femoral artery n=3, popliteal artery n=2, posterior tibial artery n=1). Atheroablation achieved a significant increase in lumen area (LA) (preintervention 3.9+/-0.4, postatheroablation 8.0+/-1.7 mm(2), P<.05), and significant reduction in plaque area (27.5+/-4.0, 23.7+/-3.1 mm(2), P=.001), while there was no change in the vessel area (31.3+/-4.2, 32.1+/-2.8 mm(2), P=.4). LBB was 57.4+/-51.3%. CONCLUSION: This novel rotational aspiration atherectomy device achieved significant luminal gain by debulking in the absence of vessel stretching. The LA was greater than burr-sized lumen expectancy at cross-sections along the treated segments, suggesting a complimentary role of aspiration in luminal gain in atherosclerotic peripheral artery lesions. |
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Authors:
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Ali H M Hassan; Junya Ako; Katsuhisa Waseda; Yasuhiro Honda; Thomas Zeller; Martin B Leon; Peter J Fitzgerald |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Cardiovascular revascularization medicine : including molecular interventions Volume: 11 ISSN: 1878-0938 ISO Abbreviation: Cardiovasc Revasc Med Publication Date: 2010 Jul-Sep |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101238551 Medline TA: Cardiovasc Revasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 155-8 Citation Subset: IM |
Affiliation:
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Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, CA 94305-5637, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atherectomy / instrumentation*, methods Atherectomy, Coronary / instrumentation, methods Chi-Square Distribution Equipment Design Equipment Safety Female Follow-Up Studies Humans Male Peripheral Vascular Diseases / therapy*, ultrasonography* Prospective Studies Risk Assessment Severity of Illness Index Survival Rate Treatment Outcome Ultrasonography, Interventional* Vascular Patency / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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