Document Detail

Mechanism of the lethal and mutagenic effects of phenoxyacetic acids in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  384215     Owner:  NLM     Status:  MEDLINE    
MCPA and salicylic acid, two compounds with similar structures and almost the same dissociation pattern, were tested for lethal and mutagenic effects on, and uptake by, cells of Saccharomyces cerevisiae strain rad18. The results obtained with the two compounds were similar, suggesting a common mechanism of action. It is proposed that they act by increasing the concentration of hydrogen ions within the cell, so that killing and mutation occur. Mutations were induced only when killing reached 95--99%. The compounds are considered weak mutagens for yeast cells. The methyl ester of MCPA also induced killing and reverse mutation, but only at concentrations about 100 times higher than for the undissociated acid. MCPA methyl ester did not increase the number of revertants in the Salmonella/liver microsome test. It is suggested that the effects of the methyl ester of MCPA depends on the ester being hydrolysed to the acid by yeast cells and the liver microsome preparation.
G Zetterberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  60     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  291-300     Citation Subset:  IM    
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MeSH Terms
Drug Evaluation, Preclinical
Genetic Techniques
Glycolates / pharmacology*
Phenoxyacetates / metabolism,  pharmacology*
Saccharomyces cerevisiae / genetics*,  metabolism
Salmonella typhimurium / genetics
Reg. No./Substance:
0/Glycolates; 0/Mutagens; 0/Phenoxyacetates

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