Document Detail

Mechanism of ischemic mitral regurgitation.
MedLine Citation:
PMID:  18522789     Owner:  NLM     Status:  In-Process    
The basic mechanism of ischemic mitral regurgitation (MR) is believed augmented leaflet tethering due to the outward displacement of the papillary muscles by left ventricular (LV) remodeling or dilatation. Annular dilatation and LV dysfunction may not be the central mechanism, but contribute to the development of MR in the presence of augmented tethering. Papillary muscle dysfunction was initially expected to cause leaflet prolapse and MR. However, multiple studies have confirmed that papillary muscle dysfunction per se does not usually cause ischemic MR and recent studies further suggest that papillary muscle dysfunction may occasionally attenuate tethering and MR. Although surgical annuloplasty is usually effective to treat ischemic MR, occasional patients with persistent or recurrent ischemic MR after surgical ring annuloplasty even with advanced downsizing suggest the need for approaches to address tethering. Finally, leaflet tethering in patients with ischemic MR can be heterogeneous, indicating the need for individualized approaches to correct ischemic MR in affected patients.
Yutaka Otsuji; Robert A Levine; Masaaki Takeuchi; Ryuzo Sakata; Chuwa Tei
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-29
Journal Detail:
Title:  Journal of cardiology     Volume:  51     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  145-56     Citation Subset:  IM    
Second Department of Internal Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
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MeSH Terms
Comment In:
J Cardiol. 2008 Oct;52(2):167-8   [PMID:  18922393 ]

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