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Mechanism of increased susceptibility to fibrillation of the hypothermic mammalian heart in situ.
MedLine Citation:
PMID:  19108158     Owner:  PIP     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The susceptibility of auricles and ventricles to fibrillation during hypothermia of isolated hearts, and of hearts in situ in anaesthetized cats, was estimated by measuring the threshold for the production of fibrillation by electrical stimulation. Hypothermia reduced the threshold of in situ hearts, but increased the threshold of isolated perfused hearts and of heart-lung preparations. The increased sensitivity of in situ hearts to fibrillation could be induced by cooling the head only, and was abolished by cutting the vagi. At normal body temperature, section of the vagi had no influence on the fibrillation threshold. In contrast, cutting the sympathetic increased the fibrillation threshold of in situ hearts at normal temperature, but had no influence on the threshold during hypothermia. It was concluded that the increased susceptibility of anaesthetized animals to fibrillation could be attributed to changes in the central nervous control of the heart induced by the cooling of the head.
Authors:
L Szekeres; J Méhes; J Papp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  17     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1961 Oct 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-07-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-75     Citation Subset:  -    
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