Document Detail


Mechanism of graft failure in HLA-matched and HLA-mismatched bone marrow transplant recipients.
MedLine Citation:
PMID:  2659109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report characterizes the mechanism of graft failure in five patients who received allogeneic marrow depleted of T cells in vitro using anti-T12 (CD6) monoclonal antibody and rabbit complement. This group of five patients represents all patients who experienced early graft failure in a larger group of 59 consecutive patients given T12 depleted marrow over a 5-year period. Although all patients received ablative pre-transplant conditioning including total body irradiation (12-14 Gy) graft failure was more frequent in patients without genetically HLA-identical donors (four of 11 patients) than in patients with HLA identical sibling donors (one of 48 patients). In patients without genotypically identical donors, graft failure was observed with variable degrees of genetic disparity including two patients with HLA haplotype-mismatched sibling donors, one patient with a phenotypically HLA-matched parental donor, and one patient with an HLA-matched unrelated donor. In patients with both HLA identical and non-identical donors, results of immunophenotypic analysis demonstrated that early graft failure was associated with peripheral lymphocytosis with T cells expressing CD2, CD3, CD5, CD6, CD8 and Ia antigens. Direct cytotoxicity studies demonstrated specific lysis of donor cells by circulating lymphocytes and further analysis indicated that effector cells were derived from the recipients and not donors. Taken together, these results suggest that these allogeneic grafts did not 'fail', but rather that residual host cytotoxic T cells were responsible for active rejection of donor marrow.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
L D Bosserman; C Murray; T Takvorian; K C Anderson; A S Freedman; J Fitzsimmons; F Coral; L M Nadler; S F Schlossman; J Ritz
Related Documents :
6524599 - Close genetic linkage between hla and renal glycosuria.
19879949 - Outcome of transplantation for myelofibrosis.
24458029 - Successful endourological management of the 'forgotten' stent in a transplanted kidney.
12853199 - Fetal hla typing in beta thalassaemia: implications for haemopoietic stem-cell transpla...
24517659 - Hypothermia risk in renal treatment.
19861859 - Impact of ethnicity, donor status and hla matching on renal allograft survival: a singl...
25280659 - A new simplified technique of arterial reconstruction in pediatric living-donor liver t...
15821839 - Administration of vascular endothelial growth factor adjunctive to fetal cardiomyocyte ...
8369879 - Experimental study on growth of epiphysial plate: free graft in rabbits.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  4     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-07-27     Completed Date:  1989-07-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
Affiliation:
Division of Tumor Immunology, Dana-Farber Cancer Institute, Harvard Medical School, MA 02115.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Bone Marrow Transplantation*
Female
Graft Rejection*
HLA Antigens*
Humans
Lymphocyte Depletion
Male
Phenotype
T-Lymphocytes, Cytotoxic / immunology
Transplantation, Homologous
Whole-Body Irradiation
Grant Support
ID/Acronym/Agency:
N01-AI-62531/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Expression of MHC class I and II antigens by keratinocytes and enterocytes in acute graft-versus-hos...
Next Document:  Consensus among bone marrow transplanters for diagnosis, grading and treatment of chronic graft-vers...