Document Detail


Mechanism of cisplatin resistance in human urothelial carcinoma cells.
MedLine Citation:
PMID:  22326969     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An isogenic pair of cisplatin-susceptible (NTUB1) and -resistant (NTUB1/P) human urothelial carcinoma cell lines was used to elucidate the mechanism of cisplatin resistance. The significantly lower intracellular platinum (IP) concentration, which resulted from the decreased cisplatin uptake, was found in NTUB1/P cells. The enhancement of IP concentration did not increase the susceptibility of NTUB1/P cells to cisplatin treatment. The reduction of IP concentration as well was unable to enhance the cisplatin-resistance in susceptible NTUB1 cells. This indicated that reduction of IP concentration was not the account for the development of cisplatin resistance here. Instead, the over expression of anti-apoptotic Bcl-2, anti-oxidative heme oxygenase-1 (HO-1) and cell cycle regulator p16INK4 seemed to be more important for the gaining of cisplatin in these human urothelial carcinoma cell.
Authors:
Yu Hui-Min; Wang Tsing-Cheng
Related Documents :
14985429 - Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pat...
15821129 - Pldb, a putative phospholipase d homologue in dictyostelium discoideum mediates quorum ...
8842809 - Pc12 cell aggregation and neurite growth in gels of collagen, laminin and fibronectin.
22484209 - Inhibition of p-glycoprotein functionality by vandetanib may reverse cancer cell resist...
15470429 - Pleiotropy as a mechanism to stabilize cooperation.
12578309 - Motility of three strains of proteus mirabilis (g9, p11 and pm5c) in liquid suspension ...
9448099 - Anti-proliferative effect of toremifene and tamoxifen on estrogen receptor-lacking anap...
14475649 - Continuous culture of a melanotic cell line from the golden hamster.
24585959 - Three-dimensional culture of hela-fucci cells for study of bystander cell-cycle effect ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-4
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Graduate Institute of Life Sciences, National Defense Medical Center, 161Minquan E. Road, Section 6, Neihu Dist., Taipei City 114, Taiwan, ROC.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced ne...
Next Document:  Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimul...