| Mechanism of cell damage by ultrasound in combination with hematoporphyrin. | |
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MedLine Citation:
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PMID: 2172198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanism of cell damage by ultrasound in combination with hematoporphyrin was studied. Mouse sarcoma 180 cell suspensions were exposed to ultrasound for up to 60 s in the presence and absence of hematoporphyrin, with and without active oxygen scavengers. The cell damage enhancement by hematoporphyrin was suppressed by adding histidine but not by mannitol. The enhancement was doubled in rate by substitution of deuterium oxide medium for normal water. Sonoluminescence was produced in a saline solution under similar acoustic conditions and observed to have spectral components that can excite hematoporphyrin molecules. These results suggest that cell damage enhancement is probably mediated via singlet oxygen generated by ultrasonically activated hematoporphyrin. |
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Authors:
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S Umemura; N Yumita; R Nishigaki; K Umemura |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese journal of cancer research : Gann Volume: 81 ISSN: 0910-5050 ISO Abbreviation: Jpn. J. Cancer Res. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-12-13 Completed Date: 1990-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8509412 Medline TA: Jpn J Cancer Res Country: JAPAN |
Other Details:
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Languages: eng Pagination: 962-6 Citation Subset: IM |
Affiliation:
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Central Research Laboratory, Hitachi, Ltd., Tokyo. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival / drug effects* Deuterium Deuterium Oxide Free Radicals Hematoporphyrins / toxicity* Histidine / pharmacology Luminescent Measurements Mannitol / pharmacology Sarcoma, Experimental / drug therapy Superoxide Dismutase / metabolism Temperature Tumor Cells, Cultured Ultrasonics* Water |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Hematoporphyrins; 69-65-8/Mannitol; 71-00-1/Histidine; 7732-18-5/Water; 7782-39-0/Deuterium; 7789-20-0/Deuterium Oxide; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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