| Mechanism of cardiovascular actions of heptanolamines. | |
| | |
MedLine Citation:
|
PMID: 13897064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has been suggested that heptaminol and methylheptaminol should be used as myocardial stimulants because they have cardiotonic actions similar to those of cardiac glycosides. However, as these aliphatic amines show definite sympathomimetic effects, the mechanism of their actions on the heart was investigated, in order to determine whether digitalis-like properties are involved in these effects. The pattern of pharmacological actions of heptaminol and methylheptaminol was compared with that of catechol amines, tyramine and k-strophanthin. The influence of atropine, hexamethonium, cocaine and reserpine was also investigated. The results show that both heptanolamines have a long-lasting cardiostimulant action which is abolished by cocaine and absent in reserpine pretreated animals. The pharmacological activity of these drugs may be entirely attributed to an indirect sympathomimetic action of the tyramine type, probably due to release of endogenous catechol amines. None of the experimental findings is consistent with the alleged digitalis-like action of these compounds. |
| | |
Authors:
|
J GARRETT; W OSSWALD; M GONCALVES MOREIRA |
Related Documents
:
|
6619384 - Inhibition of wound healing by topical steroids. 12123794 - The f-helix of serpins plays an essential, active role in the proteinase inhibition mec... 15216884 - The straight and curved conformation of ftsz protofilaments-evidence for rapid exchange... 2720874 - Pulling versus guiding: a modification of retrograde guided intubation. 7435714 - Religiousness, conversion, and subjective well-being: the "healthy-minded" religion of ... 19807304 - Economic implications of current and future provision of english learning disability he... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of pharmacology and chemotherapy Volume: 18 ISSN: 0366-0826 ISO Abbreviation: Br J Pharmacol Chemother Publication Date: 1962 Feb |
Date Detail:
|
Created Date: 1962-12-01 Completed Date: 1998-11-01 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0154627 Medline TA: Br J Pharmacol Chemother Country: Not Available |
Other Details:
|
Languages: eng Pagination: 49-60 Citation Subset: OM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Alcohols
/
pharmacology* Heart / pharmacology* Sympathomimetics / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Amino Alcohols; 0/Sympathomimetics |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glass electrodes sensitive to divalent cations.
Next Document: Methods of testing combined antibiotic bactericidal action and the significance of the results.