Document Detail

Mechanism by which neutral phosphate infusion elevates urine PCO2.
MedLine Citation:
PMID:  16069     Owner:  NLM     Status:  MEDLINE    
Currently, the ability to elevate the urine PCO2 above that of the arterial blood is employed as an estimate of distal hydrogen ion secretion. Therefore, it is important to establish the mechanisms by which various factors affect the urine CO2 tension. This paper examines the physiologic process by which phosphate elevates the urine PCO2 in the dog. The rise in urine PCO2 due to phosphate could be the result of either (1) a distal mechanism, by affecting the delayed dehydration of carbonic acid, or (2) an increase in the medullary PCO2. The phosphate-induced elevation of urine PCO2 was abolished by carbonic anhydrase infusion. This indicates that a distal mechanism is a major factor in the phosphate effect. Since acid phosphate infusion did not result in an elevated urine PCO2, it is unlikely that changes in the medullary PCO2 occur as a ry an increase in net acid excretion, indicating an increase in hydrogen ion secretion. The increased hydrogen ion secretion and rise in urine PCO2 were reproduced by infusion of the buffer, Tris-(hydroxymethyl)-aminomethane, but not by sodium sulfate administration. These findings suggest that the phosphate-induced rise in urine PCO2 is due to the buffer properties of phosphate rather than to its nonreabsorable anion characteristics.
B J Stinebaugh; F X Schloeder; E Gharafry; W N Suki; M B Goldstein; M L Halperin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  89     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  946-58     Citation Subset:  AIM; IM    
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MeSH Terms
Carbon Dioxide / urine*
Carbonic Anhydrases / pharmacology
Hydrogen-Ion Concentration
Infusions, Parenteral
Kidney / physiology*
Kidney Medulla / physiology*
Kidney Tubules / physiology*
Kidney Tubules, Distal / physiology*
Parathyroid Glands / physiology
Phosphates / administration & dosage,  antagonists & inhibitors,  pharmacology*
Thyroid Gland / physiology
Reg. No./Substance:
0/Phosphates; 124-38-9/Carbon Dioxide; EC Anhydrases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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