| Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes. | |
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MedLine Citation:
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PMID: 23024697 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The effects of polyphenols extracted from Sambucus nigra fruit were studied in streptozotocin- (STZ-) induced hyperglycemic rats to evaluate its possible antioxidant, anti-inflammatory, antiglycosylation activity, and antiosteoporosis effects in diabetes. DEXA bone mineral density tests were performed in order to determine bone mineral density (BMD), bone mineral content (BMC), and fat (%Fat) in control and diabetic animals, before and after polyphenol delivery. As compared to the normoglycemic group, the rats treated with STZ (60 mg/kg body weight) revealed a significant malondialdehyde (MDA) increase, as an index of the lipid peroxidation level, by 69%, while the total antioxidant activity (TAS) dropped by 36%, with a consistently significant decrease (P < 0.05) in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX). Also, the treatment of rats with STZ revealed a significant increase of IL-6, glycosylated haemoglobin (HbA(1c)), and osteopenia detected by DEXA bone mineral density tests. The recorded results highlight a significant improvement (P < 0.001) in the antioxidative capacity of the serum in diabetic rats treated with natural polyphenols, bringing back to normal the concentration of reduced glutathione (GSH), as well as an important decrease in the serum concentration of MDA, with improved osteoporosis status. Knowing the effects of polyphenols could lead to the use of the polyphenolic extract of Sambucus nigra as a dietary supplement in diabetic osteoporosis. |
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Authors:
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Laurentiu Badescu; Oana Badulescu; Magda Badescu; Manuela Ciocoiu |
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Publication Detail:
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Type: Journal Article Date: 2012-09-13 |
Journal Detail:
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Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2012 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-01 Completed Date: 2012-10-02 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: United States |
Other Details:
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Languages: eng Pagination: 848269 Citation Subset: - |
Affiliation:
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Department of Cellular and Molecular Biology, University of Medicine and Pharmacy "Grigore T. Popa" Iasi, 16 Universitatii Street, 700115 Iasi, Romania. |
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