Document Detail


Mechanism of bronchoconstrictive effects of aerosolized buffered saline in asthmatics.
MedLine Citation:
PMID:  6204561     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bronchoconstriction, measured by spirometry and body plethysmography, has been reported with deep breaths of air and of aerosolized buffered saline (ABS) (0.5% sodium chloride and phosphate buffer), in some stable asthmatics. To investigate the mechanisms of this phenomenon, we measured airway resistance (Raw) and functional residual capacity (FRC) in ten asthmatics after deep breaths of ABS, tidal breaths of ABS, tidal breaths of unbuffered normal saline (0.9% sodium chloride) and tidal breaths of 0.5% sodium chloride (ABS without phosphate) on different days. Raw and FRC increased with deep breaths and tidal breaths of ABS in all asthmatics, but not with tidal breaths of normal saline and unbuffered 0.5% sodium chloride. Thus the phosphate buffer rather than the hypoosmolarity of aerosolized buffered saline causes bronchoconstriction in asthmatics.
Authors:
T S Chadha; I Danta; M A Sackner
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of allergy     Volume:  53     ISSN:  0003-4738     ISO Abbreviation:  Ann Allergy     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-08     Completed Date:  1984-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372346     Medline TA:  Ann Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aerosols
Bronchial Provocation Tests
Bronchial Spasm / drug therapy
Double-Blind Method
Female
Histamine Release
Humans
Lung / physiopathology
Male
Mast Cells / metabolism
Sodium Chloride / administration & dosage,  pharmacology*
Grant Support
ID/Acronym/Agency:
HL 10622/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aerosols; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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