| Mechanism-based cancer risk assessment of butylated hydroxyanisole. | |
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MedLine Citation:
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PMID: 8418517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The evidence for BHA-induced carcinogenicity is restricted to the rodent non-glandular stomach, which is not found in humans. Although an argument can be made that an effect in this target organ could be indicative of potential carcinogenicity in other tissues, particularly the esophagus, studies have not revealed such a correlation. BHA-induced proliferative effects, which appear to be critical for the tumorigenic response, show a NOEL at a dose below that yielding benign tumors. The NOEL of this BHA-induced proliferative effect demonstrates a substantial margin of safety compared to human intake of BHA. Thus based on both dose-response considerations and the species-specific response, the use of BHA as a food additive does not pose a carcinogenic risk in humans. |
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Authors:
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J Whysner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology and industrial health Volume: 9 ISSN: 0748-2337 ISO Abbreviation: Toxicol Ind Health Publication Date: 1993 Jan-Apr |
Date Detail:
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Created Date: 1993-02-04 Completed Date: 1993-02-04 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8602702 Medline TA: Toxicol Ind Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 283-93 Citation Subset: IM |
Affiliation:
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Environmental Health and Safety Council, American Health Foundation, Valhalla, NY 10595. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Butylated Hydroxyanisole / adverse effects*, metabolism* Carcinogenicity Tests Carcinoma, Squamous Cell / chemically induced* Cell Division / drug effects Cocarcinogenesis Cricetinae Dogs Dose-Response Relationship, Drug Esophagus / drug effects Female Health Status Indicators Hyperplasia / chemically induced Macaca fascicularis Male Mesocricetus Papilloma / chemically induced* Rats Rats, Inbred F344 Rats, Wistar Shrews Species Specificity Stomach / pathology* Stomach Neoplasms / chemically induced* Swine |
| Chemical | |
Reg. No./Substance:
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25013-16-5/Butylated Hydroxyanisole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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