Document Detail


Mechanism of the antiviral action of 3-methyleneoxindole.
MedLine Citation:
PMID:  4376909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biochemical basis underlying the antiviral action of 3-methyleneoxindole (MO), a plant metabolite, was examined in HeLa cells infected with poliovirus. In the presence of antiviral concentrations of MO, poliovirus-specific ribonucleic acid (RNA) synthesis can proceed normally, and the RNA synthesized under such conditions is infectious. It is suggested that the ability of MO to bind to ribosomes of HeLa cells may underlie the antiviral affect. Data are presented which indicate that poliovirus messenger RNA cannot attach to those ribosomes which already are bound to MO. Consequently, virus-specific polysomes cannot be recovered from infected cells treated with antiviral concentrations of MO. In contrast, antiviral concentrations of MO do not prevent the formation of polysomes in uninfected HeLa cells.
Authors:
V Tuli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  5     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1974 May 
Date Detail:
Created Date:  1975-08-18     Completed Date:  1975-08-18     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  485-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / pharmacology*
Hela Cells / drug effects
Humans
Indoles / pharmacology*
Poliovirus / drug effects*
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Indoles
Comments/Corrections

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