Document Detail

Mechanism of the antiviral action of 3-methyleneoxindole.
MedLine Citation:
PMID:  4376909     Owner:  NLM     Status:  MEDLINE    
The biochemical basis underlying the antiviral action of 3-methyleneoxindole (MO), a plant metabolite, was examined in HeLa cells infected with poliovirus. In the presence of antiviral concentrations of MO, poliovirus-specific ribonucleic acid (RNA) synthesis can proceed normally, and the RNA synthesized under such conditions is infectious. It is suggested that the ability of MO to bind to ribosomes of HeLa cells may underlie the antiviral affect. Data are presented which indicate that poliovirus messenger RNA cannot attach to those ribosomes which already are bound to MO. Consequently, virus-specific polysomes cannot be recovered from infected cells treated with antiviral concentrations of MO. In contrast, antiviral concentrations of MO do not prevent the formation of polysomes in uninfected HeLa cells.
V Tuli
Related Documents :
19091579 - The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation...
7684469 - The adenovirus l3 23-kilodalton proteinase cleaves the amino-terminal head domain from ...
19246129 - Synthesis of 2-styrylchromones as a novel class of antiproliferative agents targeting c...
9623919 - Human immunodeficiency virus type 1 (hiv-1) infection and transcytosis activity of a hi...
17625509 - The efficiency of nonsense-mediated mrna decay is an inherent character and varies amon...
9136899 - Icrf-193, a catalytic inhibitor of dna topoisomerase ii, delays the cell cycle progress...
8146169 - Overexpression of the beta 1 thyroid receptor induces differentiation in neuro-2a cells.
9879459 - Video-enhanced microscopic visualization of apoptotic cell death caused by anti-fas ant...
16838369 - Transplantation of embryonic neuroectodermal progenitor cells into the site of a photoc...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  5     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1974 May 
Date Detail:
Created Date:  1975-08-18     Completed Date:  1975-08-18     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  485-91     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antiviral Agents / pharmacology*
Hela Cells / drug effects
Indoles / pharmacology*
Poliovirus / drug effects*
Reg. No./Substance:
0/Antiviral Agents; 0/Indoles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Congocidine and distamycin A, antipoxvirus antibiotics.
Next Document:  Studies on the structure and activity of rabbit Clq (a subcomponent of the first component of comple...